Skip to main content

Table 4 Relationships between selected echocardiographic parameters and molecular markers related to myocardial remodelling assessed in left ventricle and HF in male and female pigs with and without tachycardia-induced cardiomyopathy (the results of Spearman’s rank correlation coefficients)

From: Sex differences in porcine left ventricular myocardial remodeling due to right ventricular pacing

Variables (units)

Male

Female

r

p

r

p

LVEF (%)

−0.76

<0.001

−0.54

0.03

LVEDV (ml)

0.76

<0.001

0.18

0.50

LVEDV, relative increase (%)

−0.42

0.04

−0.2

0.47

LA/Ao

0.78

<0.001

0.62

0.009

RWTd

−0.56

0.002

−0.23

0.38

Em/Am

0.20

0.35

−0.07

0.78

BNP, mRNA (AU)

0.74

<0.001

0.75

<0.001

GATA4, mRNA (AU)

0.63

0.004

0.49

0.06

TGF-β1, mRNA (AU)

0.61

0.001

0.13

0.63

MMP9, mRNA (AU)

−0.08

0.71

0.00

0.99

TIMP1, mRNA (AU)

−0.04

0.84

0.17

0.54

NGAL, mRNA (AU)

−0.59

0.002

0.16

0.54

Col1A1, mRNA (AU)

0.31

0.14

−0.23

0.41

Col1A2, mRNA (AU)

0.20

0.33

−0.33

0.23

Col3A1, mRNA (AU)

0.09

0.65

−0.24

0.41

Water soluble collagen (μg/mg wet tissue)

−0.41

0.06

0.06

0.85

Total recoverable collagen (μg/mg wet tissue)

−0.16

0.44

−0.19

0.53

Total gelatinolytic activity (AU)

−0.49

0.02

−0.32

0.31

Cross-sectional cardiomyocyte diameter (μm)

−0.36

0.09

0.53

0.08

  1. LVEF left ventricle ejection fraction, LVEDV left ventricle end-diastolic volume, LVEDV, relative increase (LVEDV in end-point/LVEDV 1 month before euthanasia)*100 %, LA/Ao left atrial/aorta ratio, RWTd relative wall thickness at end diastole (2 × LVPWd/LVEDD, LVPWd end-diastolic thickness of left ventricle posterior wall, LVEDD left ventrical end-diastolic diameter), Em/Am the ratio of an early and late diastolic velocity, BNP B-type natriuretic peptide, GATA4 GATA binding protein 4, TGF-β1 transforming growth factor β1, MMP9 matrix metalloproteinase type 9, NGAL neutrophil gelatinase-associated lipocalin, TIMP1 tissue inhibitor of metalloproteinases type 1, Col1A1 collagen, type I, alpha 1, Col1A2 collagen type I, alpha 2, Col3A1 collagen type III, alpha 1