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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states

Fig. 5

Increased induction of Cxcl5 in males is a common feature of I/R and other acute inflammatory responses. ad Male and female C57BL6 mice were subjected to bilateral renal ischemia for 30 min followed by 24-h reperfusion (n = 4 mice/group). a Renal tissue Cxcl5 mRNA and b circulating GR1hi neutrophils. ce Carrageenan pleurisy was induced in male and female Wistar rats (0.15 ml of 1 % w/v, 3 h, n = 8 rats/group). c Excess volume of fluid recovered from pleural cavity (lung edema), d lung tissue Cxcl5 mRNA, e bone marrow Cxcl5 protein. Levels of mRNA are normalized to 18S and calculated as fold expression relative to mean value in males. Data are presented as mean ± sem. *P < 0.05 and **P < 0.01 by two-tailed unpaired Student’s t test. fi Cantharidin-induced skin blisters in healthy male and female volunteers. f Blister volume (edema), g blister neutrophils and monocytes, measured by cytometry, h blister fluid CXCL6 protein, and i correlation between blister CXCL6 and neutrophils. Individual data points represent one volunteer. Blister samples were analyzed by non-parametric Mann-Whitney test

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