|
Steroidogenesis and hormone receptors
|
|
cyp19a1a
a
|
Aromatase a (gonad isoform)
|
c75632_g1_i1
|
F
|
F [19, 20, 47, 110, 137, 180, 181]
|
|
cyp11c1/b2
|
Steroid 11β-hydroxylase
|
c112162_g1_i1
|
M
|
M [20, 21, 49, 137]
|
|
hsd11b2
|
11β-Hydroxysteroid dehydrogenase type 2
|
c117833_g1_i1
|
M
|
M [21, 47]
|
|
hsd11b3
|
11β-Hydroxysteroid dehydrogenase type 3 (or 1 like a)
|
c71474_g1_i1
|
F
|
NSD [47]
|
|
cyp17a1
|
Steroid 17α-hydroxylase 1
|
c152588_g2_i1
|
M
|
M [21, 47, 110]
|
|
hsd17b1
|
17β-Hydroxysteroid dehydrogenase type 1
|
c33723_g1_i1
|
F
|
F [47]
|
|
hsd17b3
|
17β-Hydroxysteroid dehydrogenase type 3
|
c3610_g1_i1
|
M
|
NSD [47]
|
|
cyp11a1
|
Cholesterol side-chain cleaving enzyme
|
c152363_g1_i1
|
M
|
M [47]
|
|
star-like
|
Steroidogenic acute regulatory protein
|
c156452_g1_i1
|
M
|
M [47]
|
|
esr1
|
Estrogen receptor alpha
|
c73327_g1_i1
|
M
|
M [21, 47, 110]
|
|
esr2a
|
Estrogen receptor beta 1
|
c70616_g1_i1
|
M
|
F [47]
|
|
esr2b
|
Estrogen receptor beta 2
|
c110359_g1_i1
|
M but NSD
|
M [47, 182]
|
|
fshr
|
Follicle-stimulating hormone receptor
|
c152458_g1_i1
|
M
|
M [183] or NSD [182]
|
|
lhr
a
|
Luteinizing hormone receptor
|
c74538_g1_i1
|
M
|
NSD [182]
|
|
nr3c1
|
Glucocorticoid receptor
|
c4332_g1_i1
|
M
| |
|
nr3c2
|
Mineralocorticoid receptor
|
c1060_g1_i1
|
F
| |
|
Key sex-related transcription factors
|
|
dmrt1
|
Doublesex- and mab-3-related transcription factor 1
|
c154918_g1_i1_split_1
|
M
|
M [21, 49, 137, 184–188]
|
|
dmrt2(a)
|
Doublesex- and mab-3-related transcription factor 2(a)
|
c155062_g1_i1
|
M
| |
|
dmrt1a1
a
|
Doublesex- and mab-3-related transcription factor like A1
|
c90860_g1_i1
|
M
| |
|
foxl2
|
Forkhead box L2
|
c29733_g1_i1
|
F
|
F [19, 46, 49, 110, 125, 127, 133] or NSD [21, 135]
|
|
foxl3
|
Forkhead box L3
|
c158785_g1_i1
|
M
|
M [125]
|
|
sf-1
|
Steroidogenic factor-1
|
c152032_g1_i1
|
M
|
M [20, 49, 110]
|
|
amh
|
Anti-Müllerian hormone or Müllerian-inhibiting substance
|
c115827_g1_i1
|
M
|
M [20, 21, 49, 189]
|
|
amhr2
|
Anti-Müllerian hormone receptor 2
|
c197093_g1_i1
|
M
|
M [34, 189]
|
|
gsdf
|
Gonadal soma derived factor
|
c69648_g1_i1-a
|
M
|
M [48, 190]
|
|
sox2
|
SRY-related HMG box 2
|
c32495_g1_i1
|
F
| |
|
sox3
a
|
SRY-related HMG box 3
|
c72647_g1_i1
|
F
|
F [191] or M [186, 192]
|
|
sox8
|
SRY-related HMG box 8
|
c75695_g1_i1
|
M
|
M [193]
|
|
sox9a
|
SRY-related HMG box 9a
|
c4248_g1_i1
|
M
|
M [49, 110, 185, 191, 194] or F [137, 195]
|
|
sox9b
a
|
SRY-related HMG box 9b
|
c193758_g2_i1
|
M
|
M [196] or F [137, 185, 194]
|
|
wt-1a
a
|
Wilms tumor protein 1a
|
c32767_g1_i1
|
M
|
M [20, 21] or F [137]
|
|
wt-1b
|
Wilms tumor protein 1b
|
c29263_g1_i1
|
M but NSD
|
M [20] or F [137]
|
|
dax1/nr0b1
|
Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1
|
c209037_g1_i1
|
F
|
M [49] or F [137, 197]
|
|
gdf9
|
Growth and differentiation factor 9
|
c152091_g1_i1
|
F
|
F [110]
|
|
fgf20b
|
Fibroblast growth factor 20-like
|
c193577_g1_i1
|
F
|
F [47]
|
|
figla
|
Factor in the germline alpha
|
c204647_g1_i1
|
F
|
F [137, 184]
|
|
Rspo1/Wnt4/β-catenin pathway
|
|
wnt4a
|
Wingless-type MMTV integration site family, member 4a
|
c167432_g1_i1
|
F but NSD
|
F [19, 137] or M [141]
|
|
wnt4b
|
Wingless-type MMTV integration site family, member 4b
|
c203717_g1_i1
|
M
|
NSD [141] or M [137]
|
|
rspo1
|
R-spondin-1 (precursor)
|
c155259_g1_i1
|
M
|
F [142] or M [137]
|
|
ctnnb1
|
Catenin (cadherin-associated protein), beta 1
|
c70814_g1_i1
|
F
|
F [20, 21, 137]
|
|
fstl3
|
Follistatin-like 3
|
c85803_g1_i1
|
M
| |
|
fstl4
a
_c1
|
Follistatin-like 4_contig1
|
c6910_g1_i1
|
M
| |
|
fstl4
a
_c2
|
Follistatin-like 4_contig2
|
c76818_g1_i1
|
F
| |
|
fstl5
|
Follistatin-like 5
|
c110224_g1_i1
|
M
| |
|
Retinoid acid signaling pathway
|
|
aldh1a2
|
Aldehyde dehydrogenase 1 family, member A2
|
c158408_g1_i1
|
M
|
M [145]
|
|
cyp26a1
|
Cytochrome P450, family 26, subfamily a, polypeptide 1
|
c29815_g1_i1
|
F
|
F [21, 145]
|
|
cyp26b1
|
Cytochrome P450, family 26, subfamily b, polypeptide 1
|
c117560_g1_i1
|
M
|
M [21] or NSD [145]
|
|
raraa
|
Retinoid acid receptor alpha a
|
c199432_g1_i1
|
F
| |
|
rarab
|
Retinoid acid receptor alpha b
|
c153705_g1_i1
|
F
| |
|
rarb
|
Retinoid acid receptor beta
|
c209577_g1_i1
|
F
| |
|
stra6
|
Stimulated by retinoic acid gene 6
|
c153800_g1_i1
|
F
|
F but NSD [21]
|
|
Epigenetic regulatory factors
|
|
piwi-like1
|
P-element induced wimpy testis (piwi) like 1
|
c1516_g1_i1
|
M
|
M [21]
|
|
dnmt1
|
DNA methyltransferase 1
|
c30017_g1_i1
|
F
| |
|
dnmt3aa
|
DNA methyltransferase 3aa
|
c755_g1_i1
|
M
| |
|
dnmt3ab
a
_c1
|
DNA methyltransferase 3ab_contig 1
|
c193863_g1_i1
|
F
| |
|
dnmt3ab
a
_c2
|
DNA methyltransferase 3ab_contig 2
|
c157308_g1_i1
|
M
| |
|
dnmt3b
|
DNA methyltransferase 3b
|
c71358_g1_i1
|
M
| |
|
dnmt3
|
DNA methyltransferase 3
|
c194062_g1_i1
|
F
| |
|
dnmt4
|
DNA methyltransferase 4
|
c161106_g1_i1
|
M
| |
|
hdac2
a
|
Histone deacetylase 2
|
c75925_g1_i1
|
F
| |
|
hdac7
|
Histone deacetylase 7
|
c193969_g1_i1
|
F
| |
|
hdac8
|
Histone deacetylase 8
|
c71086_g1_i1
|
M
| |
|
hdac10
|
Histone deacetylase 10
|
c37022_g1_i1
|
F
| |
|
hdac11
a
_c1
|
Histone deacetylase 11_contig 1
|
c152723_g1_i1
|
M
| |
|
hdac11
a
_c2
|
Histone deacetylase 11_contig 2
|
c115912_g1_i1
|
F
| |
|
Ep300a
a
|
Histone acetyltransferase—E1A binding protein 300a
|
c193959_g1_i1
|
F
| |
|
Ep300b
a
|
Histone acetyltransferase—E1A binding protein 300b
|
c112702_g1_i1
|
F
| |
|
KAT2b
|
Histone acetyltransferase—K(lysine) acetyltransferase 2b
|
c152736_g1_i1
|
M
| |
|
KAT7
a
|
Histone acetyltransferase—K(lysine) acetyltransferase 7
|
c72324_g1_i1
|
M
| |
