Sex differences in psychophysical and neurophysiological responses to pain in older adults: a cross-sectional study

Table 7 Correlations of psychophysical reports with activation in common regions located in sensory and affective pain networks (total: N = 24, male: n = 12, female: n = 12)

Region	MNI coordinate	T statistic	Overall associations		Temperature			Affect (unpleasantness)
	x, y, z		Temp	Affect	Male	Female	p value^a	Male	Female	p value^a
Mild pain < warmth			r _s	r _s	r _s	r _s		r _s	r _s
Mild pain < warmth			(p value)	(p value)	(p value)	(p value)		(p value)	(p value)
(L) dlPFC	−4 +32 +34	1.77	−0.05	0.14	0.10	−0.26	0.435	0.11	−0.06	0.719
(L) dlPFC	−4 +32 +34	1.77	(0.833)	(0.515)	(0.771)	(0.448)	0.435	(0.754)	(0.868)	0.719
(L) dACC	−6 +44 +1	2.59	−0.24	0.05	−0.05	−0.43	0.384	0.11	−0.29	0.384
(L) dACC	−6 +44 +1	2.59	(0.279)	(0.817)	(0.890)	(0.182)	0.384	(0.759)	(0.386)	0.384
(L) SMA	−12 +14 +66	2.77	−0.24	−0.12	0.07	0.13	0.897	0.22	−0.44	0.139
(L) SMA	−12 +14 +66	2.77	(0.271)	(0.603)	(0.837)	(0.723)		(0.523)	(0.172)	0.139
(L) rACC	−12 +33 +24	2.62	−0.32	0.01	−0.41	−0.01	0.368	0.34	−0.56	0.037
(L) rACC	−12 +33 +24	2.62	(0.140)	(0.996)	(0.249)	(0.985)	0.368	(0.307)	(0.080)	0.037
Moderate > warmth
(R) pINS	+51 −35 +17	2.00	0.02	0.26	0.06	−0.20	0.576	0.17	0.20	0.944
(R) pINS	+51 −35 +17	2.00	(0.936)	(0.230)	(0.865)	(0.549)	0.576	(0.621)	(0.556)	0.944
(R) SI	+60 −21 +28	2.28	0.01	0.37	0.01	−0.37	0.395	0.20	0.04	0.726
(R) SI	+60 −21 +28	2.28	(0.995)	(0.085)	(1.000)	(0.256)	0.395	(0.591)	(0.916)	0.726
(R) SII	+60 −34 +21	1.99	0.07	0.43	0.28	−0.27	0.230	0.51	0.37	0.711
(R) SII	+60 −34 +21	1.99	(0.765)	(0.043)	(0.423)	(0.419)	0.230	(0.140)	(0.262)	0.711

Values in each cell are beta and (p value). Entries in italics indicate either statistically statistic or meaningful effect sizes and respective differences
MNI Montreal Neurological Institute, L left, R right, dlPFC dorsolateral prefrontal cortex, dACC dorsal anterior cingulate cortex, SMA somatomotor area, rACC rostral anterior cingulate cortex, pINS posterior insula, SI primary somatosensory cortex, SII secondary somatosensory cortex
^a z test of independent correlations

ISSN: 2042-6410