|  | Male | Female | Main and interaction (p value) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Cytokine(ng/g) | Tissuea | Control | OF | Control | OF | Dietb | Sexc | Diet × sexd | Tissue × diete | Tissue × sexf | Tissue × diet × sexg |
CINC-1 | Ileum | 0.23 ± 0.01 | 0.25 ± 0.02 | 0.02 ± 0.02 | 0.17 ± 0.10 |  |  |  |  |  |  |
 | Cecum | 0.89 ± 0.23 | 0.69 ± 0.14 | 0.14 ± 0.14 | 0.51 ± 0.19 | 0.08 | < 0.001 | 0.007 | 0.06 | < 0.001 | NS |
 | Colon | 0.70 ± 0.12 | 0.46 ± 0.07 | 1.59 ± 0.06 | 1.75 ± 0.13 |  |  |  |  |  |  |
 | Liver | 10.95 ± 0.88 | 9.06 ± 0.96 | 6.56 ± 1.30 | 5.27 ± 0.38 |  |  |  |  |  |  |
IL-6 | Ileum | ND | ND | 1.33 ± 0.45 | 2.41 ± 0.18 |  |  |  |  |  |  |
 | Cecum | 7.85 ± 0.92 | 7.73 ± 0.86 | 5.83 ± 0.71 | 5.06 ± 0.54 | NS | < 0.001 | NS | 0.08 | < 0.001 | 0.02 |
 | Colon | 1.94 ± 0.24 | 2.45 ± 0.36 | 6.22 ± 1.17 | 4.59 ± 0.58 |  |  |  |  |  |  |
 | Liver | 159.16 ± 11.94 | 173.42 ± 18.92 | 107.77 ± 9.43 | 93.81 ± 11.67 |  |  |  |  |  |  |
TGF-β1 | Ileum | 0.47 ± 0.03 | 0.54 ± 0.04 | ND | ND |  |  |  |  |  |  |
 | Cecum | 2.45 ± 0.91 | 2.22 ± 0.89 | 2.09 ± 1.04 | 2.50 ± 1.25 | NS | NS | NS | NS | NS | NS |
 | Colon | 0.44 ± 0.01 | 0.54 ± 0.03 | 0.72 ± 0.05 | 0.72 ± 0.04 |  |  |  |  |  |  |
 | Liver | 36.97 ± 1.51 | 41.54 ± 2.24 | 39.36 ± 3.23 | 37.48 ± 4.70 |  |  |  |  |  |  |
IL-4 | Ileum | 0.14 ± 0.02 | 0.13 ± 0.03 | 0.89 ± 0.16 | 1.12 ± 0.17 |  |  |  |  |  |  |
 | Cecum | 2.92 ± 0.53 | 2.28 ± 0.37 | 1.98 ± 0.10 | 2.34 ± 0.07 | NS | < 0.001 | 0.08 | NS | < 0.001 | NS |
 | Colon | 1.06 ± 0.14 | 0.80 ± 0.07 | 3.85 ± 0.28 | 4.70 ± 0.12 |  |  |  |  |  |  |
 | Liver | 32.56 ± 0.76 | 40.98 ± 6.13 | 48.99 ± 6.22 | 45.19 ± 6.49 |  |  |  |  |  |  |
IL-10 | Ileum | 3.9 ± 0.30 | 4.92 ± 0.66 | 1.28 ± 0.2 | 1.24 ± 0.21 |  |  |  |  |  |  |
 | Cecum | 5.30 ± 0.24 | 6.48 ± 1.27 | 8.16 ± 0.84 | 6.66 ± 0.34 | NS | < 0.001 | NS | NS | < 0.001 | NS |
 | Colon | 0.95 ± 0.13 | 0.77 ± 0.12 | 10.03 ± 0.68 | 9.84 ± 0.57 |  |  |  |  |  |  |
 | Liver | 73.21 ± 4.18 | 75.39 ± 7.11 | 108.27 ± 11.09 | 111.42 ± 9.98 |  |  |  |  |  |  |