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Fig. 1 | Biology of Sex Differences

Fig. 1

From: Exogenous 17-β estradiol administration blunts progression of established angiotensin II-induced abdominal aortic aneurysms in female ovariectomized mice

Fig. 1

Exogenous E2 administration blunted progressive aortic lumen dilation and decreased AAA size in female Ovx mice. a Abdominal aortic lumen diameters quantified by ultrasound over 3 months of AngII infusions in mice from each group. At day 28, mice were stratified into groups and underwent either sham surgery (sham) or Ovx in the absence (vehicle) or presence of E2 administration (36 μg/ml by silastic tubing). Data are mean ± SEM from N = 11/12 mice/group. *P < 0.05 compared to day 28 within group. # P < 0.05 compared to sham and Ovx vehicle. b Maximal AAA diameters at study endpoint in mice from each group. Circles and inverted triangles are individual mice from each group, with mean ± SEM represented by open triangles to the right of each group. *P < 0.05 compared to Ovx vehicle. c Representative images of abdominal aortas from mice in each group. Scale bar is 2 mm

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