TY - JOUR AU - Inoshita, Masatoshi AU - Numata, Shusuke AU - Tajima, Atsushi AU - Kinoshita, Makoto AU - Umehara, Hidehiro AU - Yamamori, Hidenaga AU - Hashimoto, Ryota AU - Imoto, Issei AU - Ohmori, Tetsuro PY - 2015 DA - 2015/06/25 TI - Sex differences of leukocytes DNA methylation adjusted for estimated cellular proportions JO - Biology of Sex Differences SP - 11 VL - 6 IS - 1 AB - DNA methylation, which is most frequently the transference of a methyl group to the 5-carbon position of the cytosine in a CpG dinucleotide, plays an important role in both normal development and diseases. To date, several genome-wide methylome studies have revealed sex-biased DNA methylation, yet no studies have investigated sex differences in DNA methylation by taking into account cellular heterogeneity. The aim of the present study was to investigate sex-biased DNA methylation on the autosomes in human blood by adjusting for estimated cellular proportions because cell-type proportions may vary by sex. SN - 2042-6410 UR - https://doi.org/10.1186/s13293-015-0029-7 DO - 10.1186/s13293-015-0029-7 ID - Inoshita2015 ER -