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Table 2 Procoagulant, anticoagulant, and cellular adhesion molecules positive microvesicles from apparently healthy women and men separated by age, sex, and menopause status

From: Age- and sex-specific differences in blood-borne microvesicles from apparently healthy humans

Blood-borne microvesicles (MV) 20–70 years 20–65 years 51–70 years
Women ( N= 82) Men ( N= 62) Premenopausal women ( N= 58) Men ( N= 59) Postmenopausal women ( N= 24) Men ( N= 33)
Procoagulant positive MV/μL plasma
Phosphatidylserine MV 921* (439, 1,443) 660 (466, 1,002) 827* (354, 1,406) 652 (463, 1,002) 979 (528, 1,555) 692 (543, 942)
Tissue factor MV 17 (7, 29) 11 (5, 26) 16 (8, 29) 10 (5, 25) 21 (6, 31) 17 (4, 27)
P-selectin MV 85* (45, 202) 62 (32, 114) 90* (31, 202) 61 (32, 113) 82 (49, 302) 61 (18, 111)
Anticoagulant positive MV/μL plasma
Tissue factor pathway inhibitor MV 7 (4, 20) 6 (2, 17) 9 (4, 21) 7 (2, 18) 5 (3, 17) 8 (3, 19)
Cellular adhesion molecules positive MV/μL plasma
ICAM-1 MV 14 (7, 31) 14 (7, 29) 15 (3, 28) 13 (7, 29) 20 (9, 39) 19 (6, 31)
VCAM-1 MV 6 (3, 20) 7 (2, 16) 7 (3, 21) 7 (2, 17) 6 (4, 14) 8 (4, 21)
  1. Data are presented as median with 25th and 75th percentiles.
  2. *Statistically significant (P < 0.05) differences in concentration of MV between women and age-matched men. Statistically significant (P < 0.05) differences in concentration of MV between postmenopausal women and premenopausal women.