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Table 3 Influence of gonadectomy on sarcolemmal proteins and currents

From: Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms

Component Treatment Duration (weeks) Functional change Species Reference
Ultra-rapid delayed rectifier K+ current (IKur) aGDX 13 ↓ peak IKur Mouse [38,39]
13 ↓ Kv1.5 protein Mouse [38,39]
GDX 16 ↔ Kv1.5 protein Rat [74]
Transient outward K+ current (ITO) GDX 13 ↔ peak ITO Mouse [38]
13 ↔ Kv4.2/4.3 protein Mouse [38]
Steady state K+ current (ISS) GDX 13 ↔ peak ISS Mouse [38]
13 ↔ Kv1.2 protein Mouse [38]
Inward rectifier K+ current (IK1) GDX 13 ↔ peak IK1 Mouse [38]
13 ↔ Kir2.1 protein Mouse [38]
16 ↓ Kir2.1 mRNA Rat [74]
16 ↔ Kir2.2 mRNA Rat [74]
16 ↔ Kir2.3 mRNA Rat [74]
Slow delayed rectifier K+ current (IKs) GDX 8 ↓ peak IKs Rabbit [89]
L-type Ca2+ current (ICa-L)/ dihydropyridine receptor (DHPR) GDX 9 ↔ peak ICa-L Rabbit [40]
bGDX 2 ↓ DHPR mRNA Rat [90]
16 ↓ DHPR mRNA Rat [91]
Na + -Ca2+ exchanger GDX 10 ↔ NCX activity Rat [96]
9 ↔ NCX activity Rat [76]
2 ↔ NCX protein Rat [75]
10 ↓ NCX protein Rat [96]
  10–11 ↑ NCX protein Mouse [69]
bGDX 2 ↓ NCX mRNA Rat [90]
16 ↓ NCX mRNA Rat [91]
  1. aIndicates that the effect of GDX was reversed by treatment with dihydrotestosterone. bIndicates that the effect of GDX was reversed by treatment with testosterone.