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Table 1 Influence of chronic testosterone withdrawal on myocardial contractility

From: Testosterone modulates cardiac contraction and calcium homeostasis: cellular and molecular mechanisms

Component Model Functional change Duration of GDX (weeks) Species Reference
LVDP Langendorff 2 Rat [75]
9 Rat [76]
a 16 Rat [74]
Working heart b 3 Rat [77]
b 10 Rat [78]
LVEDP Millar catheterization 10–11 Mouse [69]
Langendorff 2 Rat [75]
Working heart b 3 Rat [77]
b 10 Rat [78]
+dP/dT Millar catheterization 10–11 Mouse [69]
Langendorff 9 Rat [76]
a 16 Rat [74]
−dP/dT Millar catheterization 10–11 Mouse [69]
Langendorff 9 Rat [76]
a 16 Rat [74]
Working heart b 3 Rat [77]
b 10 Rat [78]
  1. aEffect of GDX is reversed by testosterone replacement. bFunctional change in the working heart model was only observed at high left atrial pressures.