Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice

Table 2 Effect of GDX and DES treatment on body weight of female mice

	Sham		GDX		Two-way ANOVA results
	Vehicle	DES	Vehicle	DES	Surgery	Treatment	Interaction
BW before surgery	19.8 ± 0.4	19.6 ± 0.4	19.9 ± 0.6	19.8 ± 0.4	NS	NS	NS
BW 1 week after surgery	20.2 ± 0.5	20.1 ± 0.4	21.6 ± 0.3	21.4 ± 0.5	p < 0.005	NS	NS
Change in BW (%) 1 week after surgery	2.1 ± 0.5	3.0 ± 1.3	8.9 ± 2.5	8.3 ± 2.7	p < 0.01	NS	NS
BW after 1 week treatment	21.3 ± 0.5	23.0 ± 0.4	23.2 ± 0.2	24.1 ± 0.4	p < 0.005	p < 0.005	NS
Change in BW (%) 1 week after treatment	5.8 ± 1.0	14.3 ± 1.6	7.5 ± 1.3	12.7 ± 1.2	NS	p < 0.0001	NS

Female mice received gonadectomy (GDX) or a sham operation. After 1 week, mice were injected daily with diethylstilbestrol (DES) or olive oil vehicle for 1 week. Values are averages ± SEM; n = 6.
NS, not significant.

ISSN: 2042-6410