Figure 2
From: Estrogens increase expression of bone morphogenetic protein 8b in brown adipose tissue of mice
Female mice have higher BAT Bmp8b expression and lower BAT Fgf1 expression. (A) Body weight of male and female mice following received GDX or a sham operation. (B) Ucp1 mRNA expression in BAT of male and female mice upon GDX or sham operation. (C) Bmp4, Bmp6, and Bmp8b mRNA expression in BAT of male and female mice upon GDX or sham operation. (D) Fgf1, Fgf9, Fgf10, Fgf11, Fgf18, and Fgf21 mRNA expression in BAT of male and female mice upon GDX or sham operation. mRNA expression results were normalized to 18S ribosomal RNA (Rn18s) and beta-2 microglobulin (B2m) with data from sham-operated male mice defined as ‘1’. Values are averages ± SEM; n = 10; †p < 0.025 (Mann–Whitney U post hoc test when a significance was detected by two-way ANOVA). Depicted below the graphs are the significant p values of the two-way ANOVA tests for either sex (S), GDX (G), or the interaction between sex and GDX (SxG).