The effect of fluid flow-induced shear stress on the activity of 1G and 2G MMP-1 single nucleotide polymorphic variants. *p < 0.05 with respect to matching non-shear control, †p < 0.05 with respect to matching 1G variant. Box plots show the median, 25th and 75th percentiles (p25 and p75, lower and upper box boundaries respectively), upper and lower adjacent values (whiskers), and outside values (dots). The inter-quartile range (IQR) is defined as p75–p25. The adjacent values are defined as the highest value not greater than p75 + 3 / 2 IQR and the lowest value not less than p25 − 3 / 2 IQR.