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Table 1 The effects of age and sex on VP-induced vasoconstriction of endothelium-intact pressurized MCA segments

From: Effects of age and sex on cerebrovascular function in the rat middle cerebral artery

Group Treatment Maximal response to VP (% Constriction) Relative maximal response to VP Dilator PG Constrictor PG
MA F Control 47.7???3.7 ? - -
  COX-1 20.0???1.6   0 ???
  COX-2 33.9???2.4   0 ??
MA M Control 47.6???2.3 ? - -
  COX-1 41.3???3.1   0 ?
  COX-2 41.7???3.2   0 ?
RS F Control 32.1???2.7 ? - -
  COX-1 44.6???3.7   ?? 0
  COX-2 27.5???.7   0 0
RS M Control 45.5???3.0 ? - -
  COX-1 41.0???4.6   0 0
  COX-2 39.7???2.3   0 0
  1. The effects of age and sex on VP-induced vasoconstriction of endothelium-intact pressurized MCA segments and the relative contributions of constrictor vs. dilator prostanoids in mature multigravid adult (MA, 4?6 months) female (F) (MA F) or age-matched male (M) rats (MA M) and reproductively senescent (RS, 10?12 months) female (F) (RS F) or age-matched male (M) rats (RS M). Vasopressin (VP). Prostaglandin (PG). Treatment reflects either control vascular reactivity or reactivity in the presence of COX-1 (SC560) or COX-2 (NS398) inhibition. Arrows indicate relative differences in response.