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Table 1 Top 25 genes displaying the strongest differential expression between males and females in the intestine

From: Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice

Symbol SI Colon Chr Promoter length Number of CpGs Description
Eif2s3y −49.68 −46.96 Y 682 21 Eukaryotic translation initiation factor 2, subU 3, str. gene Y-linked
Uty −48.21 −44.48 Y 893 28 Ubiquitously transcribed tetratricopeptide repeat gene, Y chr
Ddx3y −28.71 −30.81 Y 643 23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
Kdm5d −15.67 −21.58 Y 757 30 Lysine (K)-specific demethylase 5D
Upk1b −1.12^ −1.60 16 603 11 Uroplakin 1B
Wt1 −1.02^ −1.59 2 1282 104 Wilms tumour 1 homologue
Syndig1 −1.52 −1.05^ 2 603 + 1,225 3 + 91 Synapse differentiation inducing 1
Nos2 1.09^ −1.41 11 673 8 Nitric oxide synthase 2, inducible
Rab42 −1.42 −1.17^ 4 783 35 RAB42, member RAS oncogene family
Nts§ −1.41 −1.15^ 10 794 6 Neurotensin
Cyp2c66 1.45 −1.07^ 19 613 1 Cytochrome P450, family 2, subfamily c, polypeptide 66
Mmp25 1.43 1.05^ 17 893 36 Matrix metallopeptidase 25
Slc7a11§ 1.40 1.05^ 3 829 18 Solute carrier family 7, member 11
Nucb2§ 1.46 1.07^ 7 666 36 Nucleobindin 2
Alox5ap§ 1.44 1.13^ 5 705 4 Arachidonate 5-lipoxygenase-activating protein
Gm12696 −1.13^ 1.41 4    Predicted gene 12696
Cabp2 1.50 −1.06^ 19 603 + 820 3 + 8 Calcium-binding protein 2
Fkbp11 1.56 1.09^ 15 1041 27 FK506-binding protein 11
Mcpt1 −1.02^ 1.54 14 606 5 Mast cell protease 1
Mcpt2 −1.12^ 1.66 14 601 1 Mast cell protease 2
Dleu2 −1.11^ 1.71 14 798 + 601 84 + 45 Deleted in lymphocytic leukaemia, 2
Ccr3 1.59 1.50^ 9 730 3 Chemokine (C-C motif) receptor 3
Retnl㧠1.72 1.52^ 16 638 4 Resistin-like gamma
Kdm6a 1.59 1.57 X 693 + 601 51 + 69 Lysine (K)-specific demethylase 6A
Xist 104.49 182.91 X 1,065 29 Inactive X-specific transcripts
  1. Significant ♂-dominant expression FC >1.4.
  2. Significant ♀-dominant expression FC >1.4.
  3. ^FC without a significant sexually dimorphic effect.
  4. §Previous studies revealed an intestine-specific function and/or expression of this gene.