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Table 1 Top 25 genes displaying the strongest differential expression between males and females in the intestine

From: Sexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice

Symbol

SI

Colon

Chr

Promoter length

Number of CpGs

Description

Eif2s3y

−49.68♂

−46.96♂

Y

682

21

Eukaryotic translation initiation factor 2, subU 3, str. gene Y-linked

Uty

−48.21♂

−44.48♂

Y

893

28

Ubiquitously transcribed tetratricopeptide repeat gene, Y chr

Ddx3y

−28.71♂

−30.81♂

Y

643

23

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

Kdm5d

−15.67♂

−21.58♂

Y

757

30

Lysine (K)-specific demethylase 5D

Upk1b

−1.12^

−1.60♂

16

603

11

Uroplakin 1B

Wt1

−1.02^

−1.59♂

2

1282

104

Wilms tumour 1 homologue

Syndig1

−1.52♂

−1.05^

2

603 + 1,225

3 + 91

Synapse differentiation inducing 1

Nos2

1.09^

−1.41♂

11

673

8

Nitric oxide synthase 2, inducible

Rab42

−1.42♂

−1.17^

4

783

35

RAB42, member RAS oncogene family

Nts§

−1.41♂

−1.15^

10

794

6

Neurotensin

Cyp2c66

1.45♀

−1.07^

19

613

1

Cytochrome P450, family 2, subfamily c, polypeptide 66

Mmp25

1.43♀

1.05^

17

893

36

Matrix metallopeptidase 25

Slc7a11§

1.40♀

1.05^

3

829

18

Solute carrier family 7, member 11

Nucb2§

1.46♀

1.07^

7

666

36

Nucleobindin 2

Alox5ap§

1.44♀

1.13^

5

705

4

Arachidonate 5-lipoxygenase-activating protein

Gm12696

−1.13^

1.41♀

4

  

Predicted gene 12696

Cabp2

1.50♀

−1.06^

19

603 + 820

3 + 8

Calcium-binding protein 2

Fkbp11

1.56♀

1.09^

15

1041

27

FK506-binding protein 11

Mcpt1

−1.02^

1.54♀

14

606

5

Mast cell protease 1

Mcpt2

−1.12^

1.66♀

14

601

1

Mast cell protease 2

Dleu2

−1.11^

1.71♀

14

798 + 601

84 + 45

Deleted in lymphocytic leukaemia, 2

Ccr3

1.59♀

1.50^

9

730

3

Chemokine (C-C motif) receptor 3

Retnlγ§

1.72♀

1.52^

16

638

4

Resistin-like gamma

Kdm6a

1.59♀

1.57♀

X

693 + 601

51 + 69

Lysine (K)-specific demethylase 6A

Xist

104.49♀

182.91♀

X

1,065

29

Inactive X-specific transcripts

  1. ♂Significant ♂-dominant expression FC >1.4.
  2. ♀Significant ♀-dominant expression FC >1.4.
  3. ^FC without a significant sexually dimorphic effect.
  4. §Previous studies revealed an intestine-specific function and/or expression of this gene.