The effects of perinatal testosterone exposure on the DNA methylome of the mouse brain are late-emerging

Table 4 Genes that show testosterone-driven changes in both CpG methylation and gene expression

Gene	Log₂fold change	Expression difference p value	Δ Me at PN60
Ppp2r5c	1.07	9.66E − 05	0.10
Nrxn1	0.95	3.63E − 04	0.10
Lpin1	0.71	8.18E − 05	0.10
Egln1	0.53	2.41E − 04	0.13
Bin1	0.47	2.08E − 04	0.11
Inpp5a	0.42	3.80E − 04	−0.13
Fhl1	0.40	4.11E − 05	0.15
Mras	−0.42	3.09E − 04	0.13
E130203B14Rik	−0.61	2.75E − 04	0.12
Wfdc1	−0.66	1.26E − 04	0.10

Genes that show testosterone-driven changes in both CpG methylation and gene expression in the PN60 XX vs. XX + T comparison in the striatum. Negative values in the second column indicate lower expression in XX + T relative to XX. In the fourth column, negative values indicate lower methylation in XX + T relative to XX.

ISSN: 2042-6410