The effects of perinatal testosterone exposure on the DNA methylome of the mouse brain are late-emerging

Ghahramani, Negar M; Ngun, Tuck C; Chen, Pao-Yang; Tian, Yuan; Krishnan, Sangitha; Muir, Stephanie; Rubbi, Liudmilla; Arnold, Arthur P; de Vries, Geert J; Forger, Nancy G; Pellegrini, Matteo; Vilain, Eric

doi:10.1186/2042-6410-5-8

Biology of Sex Differences

Table 3 Testosterone-driven methylation changes at several genes are maintained into adulthood

From: The effects of perinatal testosterone exposure on the DNA methylome of the mouse brain are late-emerging

Gene symbol	Δ Me at PN4	Fragment coordinate at PN4	Δ Me at PN60	Fragment coordinate at PN60	Associated genomic features
Gene symbol	Δ Me at PN4	Fragment coordinate at PN4	Δ Me at PN60	Fragment coordinate at PN60	Prom	GB	CGI
Striatum
4921515J06Rik	0.22	chr3:108742959-108743236	−0.13	chr3:108742959-108743236	X	X	X
Taf4b	−0.11	chr18:15048075-15048318	−0.1	chr18:15048075-15048318		X
F8a	−0.1	chrX:70473904-70474128	−0.13	chrX:70474305-70474419		X	X
Fmr1	−0.1	chrX:65932427-65932537	−0.11	chrX:65932427-65932537		X	X
Kcnq1	0.28	chr7:150455734-150456023	−0.14	chr7:150481372-150481523		X	X
Rbbp7	−0.23	chrX:159198854-159199070	−0.12	chrX:159198688-159198839	X	X	X
Sox3	−0.11	chrX:58145676-58145842	−0.11	chrX:58146499-58146619	X	X	X
Dab1	−0.1	chr4:104298501-104298709	−0.11	chr4:104275571-104275789		X
Nnat	−0.13	chr2:157385832-157386011	−0.12	chr2:157386045-157386214	X	X	X
Arid3b	−0.19	chr9:57685767-57685957	−0.11	chr9:57685767-57685957	X
Grip1	−0.21	chr10:119402892-119403155	−0.12	chr10:119402892-119403155		X	X
Lonrf3	−0.1	chrX:33868422-33868652	−0.12	chrX:33869078-33869231	X	X	X
Clybl	−0.15	chr14:122662639-122662815	−0.12	chr14:122629995-122630146		X
Sorcs2	−0.13	chr5:36720053-36720329	−0.12	chr5:36511861-36512058		X
2610018G03Rik	−0.11	chrX:48194982-48195124	−0.12	chrX:48194982-48195124		X	X
Rap2c	−0.17	chrX:48370998-48371218	−0.12	chrX:48370998-48371218	X	X	X
Fndc3b	0.12	chr3:27382887-27383015	−0.21	chr3:27368716-27368995		X
Ubash3b	−0.12	chr9:40872064-40872268	−0.14	chr9:40872064-40872268		X
Foxk1	−0.25	chr5:142921051-142921281	−0.27	chr5:142921051-142921281		X
BNST/POA
Igfbp7	−0.13	chr5:77809526-77809779	−0.21	chr5:77786342-77786589		X
Odz3	−0.11	chr8:49626485-49626755	0.12	chr8:49395012-49395267		X
Emd	−0.13	chrX:71500275-71500386	−0.11	chrX:71500067-71500242	X	X	X
Herc3	−0.12	chr6:58856760-58856872	−0.12	chr6:58856760-58856872	X	X	X
Commd1	−0.16	chr11:22873668-22873935	−0.12	chr11:22872579-22872758	X	X	X
Bcor	−0.14	chrX:11715730-11715985	−0.11	chrX:11703662-11703859		X
Nap1l5	−0.12	chr6:58856760-58856872	−0.12	chr6:58856760-58856872	X	X	X
Gpr179	−0.14	chr11:97193837-97194108	−0.11	chr11:97197795-97197992		X
Zrsr1	−0.16	chr11:22873668-22873935	−0.12	chr11:22872579-22872758	X	X	X
Lonrf3	−0.12	chrX:33868422-33868652	−0.1	chrX:33869078-33869231	X	X	X
Sdk1	−0.13	chr5:142590169-142590448	0.12	chr5:142312410-142312648		X

Differential CpG methylation values between XX and XX + T at PN4 and PN60 are shown. Negative delta methylation indicates higher methylation in XX + T. Genomic features associated with the differentially methylated region are indicated by the last three columns. An ‘X’ indicates that the fragment overlaps with a feature (Prom promoter, GB gene body, CGI CpG island).

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ISSN: 2042-6410

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