Workflow in GenderMedDB. An automatization was implemented to constantly update the data included in the database. In the first step of this pipeline, the complete PubMed database is downloaded via FTP server (ftp://ftp.ncbi.nlm.nih.gov/) of NCBI (National Center for Biotechnology Information) by the LingPipe package. Data are screened, indexed and transferred to the validation table of the database. Pre-selected publications are validated by two researchers and integrated into the GenderMedDB database. Users of GenderMedDB are also enabled to upload publications to the frontend, which will be incorporated into the database after quality control and integration of the categorization.