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Table 2 Statistics for experiment 2

From: Sex differences in a mouse model of multiple sclerosis: neuropathic pain behavior in females but not males and protection from neurological deficits during proestrus

Measure

Two-way RM ANOVA (treatment × time (BL–day 43))

Two-way RM ANOVA (treatment × time (days 60–90))

Clinical scores

Figure 3A

Day: F37,1221 = 21.3, P < 0.001

Day: F2,30 = 0.8, P = 0.4

Treatment: F1,33 = 21.7, P < 0.001

Treatment: F1,15 = 0.003, P = 0.9

Day × treatment: F37,1221 = 4.1, P < 0.001

Day × treatment: F2,30 = 1.7, P = 0.19

Grip strength

Figure 3B

Day: F13,429 = 17.9, P < 0.001

Day: F2,30 = 4.7, P < 0.05

Treatment: F1,33 = 22.6, P < 0.001

Treatment: F1,15 = 0.16, P = 0.6

Day × treatment: F13,429 = 0.9, P = 0.5

Day × treatment: F2,30 = 1.4, P = 0.2

Weight

Figure 3C

Day: F36,1188 = 76.3, P < 0.001

Day: F2,30 = 17.1, P < 0.001

Treatment: F1,33 = 1.0, P = 0.3

Treatment: F1,15 = 0.5, P = 0.4

Day × treatment: F36,1188 = 0.5, P = 0.9

Day × treatment: F2,30 = 0.6, P = 0.4

Mechanical thresholds

Figure 3D

Day: F13,429 = 5.5, P < 0.001

Day: F2,30 = 30.4, P = 0.06

Treatment: F1,33 = 20.9, P < 0.001

Treatment: F1,15 = 0.5, P = 0.4

Day × treatment: F13,429 = 2.8, P < 0.01

Day × treatment: F2,30 = 1.0, P = 0.3

Acetone withdrawal

Figure 3E

Day: F13,429 = 11.1, P < 0.001

Day: F2,30 = 0.5, P = 0.5

Treatment: F1,33 = 8.9, P < 0.01

Treatment: F1,15 = 0.2, P = 0.6

Day × treatment: F13,429 = 2.0, P = 0.06

Day × treatment: F2,30 = 1.6, P = 0.2

Heat latency

Figure 3F

Day: F7,231 = 1.8, P = 0.07

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Treatment: F1,33 = 1.9, P = 0.17

  

Day × treatment: F7,231 = 0.3, P = 0.9

 
  1. Treatment conditions: CFA, n = 17 (BL–day 43) or n = 8 (days 60–90). CFA + MOG35-55, n = 18 (BL–day 43) or n = 9 (days 60–90).