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Table 2 Capillary and cardiac myocyte numerical densities and capillary-to-myocyte ratio in the left ventricle of shame and MI hearts from male (M) and female (F) rats

From: Coronary vessels and cardiac myocytes of middle-aged rats demonstrate regional sex-specific adaptation in response to postmyocardial infarction remodeling

 

Number

LV free wall

Septum

CD, number/mm2

MD, number/mm2

C/M

CD, number/mm2

MD, number/mm2

C/M

Epimyocardium

       

 M-Sham

7

4,929.7 ± 407.7

3,142.9 ± 193.6

1.59 ± 0.12

N/A

N/A

N/A

 M-MI

7

3,818.1 ± 169.9*

2,178.9 ± 207.6*

1.81 ± 0.08*

N/A

N/A

N/A

 F-Sham

6

5,405.5 ± 418.9

4,027.2 ± 262.2§

1.35 ± 0.04

N/A

N/A

N/A

 F-MI

6

5,142.7 ± 773.8

3,661.4 ± 312.3††

1.39 ± 0.09†

N/A

N/A

N/A

Endomyocardium

       

 M-Sham

7

6,220.4 ± 329.9

3,739.6 ± 195.2

1.67 ± 0.05

6,107.4 ± 459.6

3,783.9 ± 286.5

1.62 ± 0.04

 M-MI

7

4,353.3 ± 687.1*

2,704.7 ± 351.0*

1.60 ± 0.06

5,215.2 ± 592.3

3,443.6 ± 262.4

1.52 ± 0.09

 F-Sham

6

5,477.4 ± 396.5

4,032.1 ± 305.2

1.36 ± 0.05§

5,361.5 ± 908.9

3,938.7 ± 346.8

1.34 ± 0.12§

 F-MI

6

4,492.8 ± 648.0

2,709.2 ± 337.3*

1.66 ± 0.13*

5,510.2 ± 717.4

3,875.4 ± 359.8

1.37 ± 0.11

  1. Values are the mean ± SEM. n, number of rats; CD, capillary density; MD, myocyte density; C/M, capillary-to-myocyte ratio; N/A, mot applicable. Note that in septum all parameters were analyzed only in LV endomyocardium. A two-way ANOVA revealed a statistically significant interaction between the effects of sex and the experimental model on the capillary-to-cardiac myocyte ratio in free wall endomyocardium, F (1, 22) = 6.307, P = 0.025. *P < 0.05 vs. corresponding Sham group; §P < 0.05 vs. M-Sham; †P < 0.05 and ††P < 0.01 vs. M-MI.
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Biology of Sex Differences

ISSN: 2042-6410

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