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Table 2 Capillary and cardiac myocyte numerical densities and capillary-to-myocyte ratio in the left ventricle of shame and MI hearts from male (M) and female (F) rats

From: Coronary vessels and cardiac myocytes of middle-aged rats demonstrate regional sex-specific adaptation in response to postmyocardial infarction remodeling

  Number LV free wall Septum
CD, number/mm2 MD, number/mm2 C/M CD, number/mm2 MD, number/mm2 C/M
Epimyocardium        
 M-Sham 7 4,929.7 ± 407.7 3,142.9 ± 193.6 1.59 ± 0.12 N/A N/A N/A
 M-MI 7 3,818.1 ± 169.9* 2,178.9 ± 207.6* 1.81 ± 0.08* N/A N/A N/A
 F-Sham 6 5,405.5 ± 418.9 4,027.2 ± 262.2§ 1.35 ± 0.04 N/A N/A N/A
 F-MI 6 5,142.7 ± 773.8 3,661.4 ± 312.3†† 1.39 ± 0.09† N/A N/A N/A
Endomyocardium        
 M-Sham 7 6,220.4 ± 329.9 3,739.6 ± 195.2 1.67 ± 0.05 6,107.4 ± 459.6 3,783.9 ± 286.5 1.62 ± 0.04
 M-MI 7 4,353.3 ± 687.1* 2,704.7 ± 351.0* 1.60 ± 0.06 5,215.2 ± 592.3 3,443.6 ± 262.4 1.52 ± 0.09
 F-Sham 6 5,477.4 ± 396.5 4,032.1 ± 305.2 1.36 ± 0.05§ 5,361.5 ± 908.9 3,938.7 ± 346.8 1.34 ± 0.12§
 F-MI 6 4,492.8 ± 648.0 2,709.2 ± 337.3* 1.66 ± 0.13* 5,510.2 ± 717.4 3,875.4 ± 359.8 1.37 ± 0.11
  1. Values are the mean ± SEM. n, number of rats; CD, capillary density; MD, myocyte density; C/M, capillary-to-myocyte ratio; N/A, mot applicable. Note that in septum all parameters were analyzed only in LV endomyocardium. A two-way ANOVA revealed a statistically significant interaction between the effects of sex and the experimental model on the capillary-to-cardiac myocyte ratio in free wall endomyocardium, F (1, 22) = 6.307, P = 0.025. *P < 0.05 vs. corresponding Sham group; §P < 0.05 vs. M-Sham; †P < 0.05 and ††P < 0.01 vs. M-MI.
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Biology of Sex Differences

ISSN: 2042-6410

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