Table 2 Anaesthetised renal function and PCR analysis of male and female spiny mice on normal or high salt diets

Mass

 Pre-diet Body Mass g

35.8 ± 0.4

35.7 ± 0.9

33.5 ± 1.0

31.8 ± 0.7

=0.001

0.29

0.35

 Post-diet Body Mass g

36.8 ± 0.6

37.1 ± 0.6

33.9 ± 0.8

32.0 ± 0.9

<0.001

0.29

0.16

 Change in Body Mass g

1.0 ± 0.3

1.4 ± 0.6

0.4 ± 0.4

0.2 ± 0.3

0.052

0.84

0.46

 Kidney Mass mg

268 ± 11

295 ± 10

263 ± 9

285 ± 8

0.42

=0.01

0.80

 KM: BM Ratio mg:g

7.27 ± 0.23

7.97 ± 0.18

7.75 ± 0.16

8.95 ± 0.33

=0.005

<0.001

0.29

Renal & Cardiovascular Measures

 MAP mmHg

62.0 ± 1.5

67.4 ± 1.7

60.3 ± 2.0

62.4 ± 1.6

0.07

=0.04

0.36

 GFR μL/min/gBM

3.66 ± 0.12

6.63 ± 0.34

3.43 ± 0.28

4.83 ± 0.51

=0.005

<0.001

=0.025

 ERPF μL/min/gBM

11.60 ± 0.54

18.36 ± 1.38

11.51 ± 1.80

17.61 ± 1.38

0.76

<0.001

0.81

 RVR mmHg/μL/min/gBM

3.03 ± 0.10

2.12 ± 0.17

3.35 ± 0.48

2.09 ± 0.15

0.62

=0.002

0.55

 Filtration Fraction%

32 ± 2

37 ± 3

32 ± 3

27 ± 1

0.07

0.95

=0.048

Renal PCR

 AQP3

1.00 ± 0.13

0.72 ± 0.14

0.75 ± 0.14

0.73 ± 0.09

0.46

0.22

0.28

 V2R

1.00 ± 0.15

0.79 ± 0.20

0.67 ± 0.12

0.91 ± 0.14

0.32

0.64

0.28