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Table 2 Anaesthetised renal function and PCR analysis of male and female spiny mice on normal or high salt diets

From: A comparative study of renal function in male and female spiny mice – sex specific responses to a high salt challenge

  Male Female Statistics
  Normal salt High salt Normal salt High salt PSEX PDIET PINT
Mass        
Pre-diet Body Mass g 35.8 ± 0.4 35.7 ± 0.9 33.5 ± 1.0 31.8 ± 0.7 =0.001 0.29 0.35
Post-diet Body Mass g 36.8 ± 0.6 37.1 ± 0.6 33.9 ± 0.8 32.0 ± 0.9 <0.001 0.29 0.16
Change in Body Mass g 1.0 ± 0.3 1.4 ± 0.6 0.4 ± 0.4 0.2 ± 0.3 0.052 0.84 0.46
Kidney Mass mg 268 ± 11 295 ± 10 263 ± 9 285 ± 8 0.42 =0.01 0.80
KM: BM Ratio mg:g 7.27 ± 0.23 7.97 ± 0.18 7.75 ± 0.16 8.95 ± 0.33 =0.005 <0.001 0.29
Renal & Cardiovascular Measures       
MAP mmHg 62.0 ± 1.5 67.4 ± 1.7 60.3 ± 2.0 62.4 ± 1.6 0.07 =0.04 0.36
GFR μL/min/gBM 3.66 ± 0.12 6.63 ± 0.34 3.43 ± 0.28 4.83 ± 0.51 =0.005 <0.001 =0.025
ERPF μL/min/gBM 11.60 ± 0.54 18.36 ± 1.38 11.51 ± 1.80 17.61 ± 1.38 0.76 <0.001 0.81
RVR mmHg/μL/min/gBM 3.03 ± 0.10 2.12 ± 0.17 3.35 ± 0.48 2.09 ± 0.15 0.62 =0.002 0.55
Filtration Fraction% 32 ± 2 37 ± 3 32 ± 3 27 ± 1 0.07 0.95 =0.048
Renal PCR        
 AQP3 1.00 ± 0.13 0.72 ± 0.14 0.75 ± 0.14 0.73 ± 0.09 0.46 0.22 0.28
 V2R 1.00 ± 0.15 0.79 ± 0.20 0.67 ± 0.12 0.91 ± 0.14 0.32 0.64 0.28
  1. Values are means ± SEM. n = 6 per sex on normal salt diet, n = 5 per sex on high salt diet. NS, non significant, g; gram, BM, body mass, KM, kidney mass, MAP, mean arterial pressure, GFR, glomerular filtration rate, ERPF, effective renal plasma flow, RVR, renal vascular resistance. Data were analysed by Two way ANOVA.