Figure 4

Weighted gene co-expression networks of all GABA-, serotonin-, and dopamine-related genes. Networks are split based on sex chromosome complement, gonadal sex, and hormone treatment. Lines connecting genes indicate co-expression of those two genes, with the weight of the line proportional to the level of co-expression. Red lines indicate positive correlation, while blue lines indicate negative correlation between genes. The size of each node indicates the degree (sum of the edge weights of all connections) for that gene. The male phenotypes (XY^-, gonadal male, testosterone-treated) were used as reference networks due to their robust effect on expression, meaning that the female data (XX, gonadal female, blank-treated) was plotted on the network structure established by the respective male phenotype.