This schematic illustrates sex differences in CRF
trafficking in LC dendrites . Under conditions of excessive release of CRF (green), CRF1 receptors (blue) internalize in male neurons (left). This effect reduces neuronal responses to CRF in males. In females (right), CRF1 receptors fail to internalize under conditions of CRF hypersecretion, resulting in greater neuronal responses to CRF in this group.