Figure 1

This schematic illustrates sex differences in CRF ₁ trafficking in LC dendrites [133]. Under conditions of excessive release of CRF (green), CRF₁ receptors (blue) internalize in male neurons (left). This effect reduces neuronal responses to CRF in males. In females (right), CRF₁ receptors fail to internalize under conditions of CRF hypersecretion, resulting in greater neuronal responses to CRF in this group.