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Figure 3 | Biology of Sex Differences

Figure 3

From: Anti-Müllerian hormone may regulate the number of calbindin-positive neurons in the sexually dimorphic nucleus of the preoptic area of male mice

Figure 3

The CALB-SDN has pre-pubescent and adult forms that are differentially regulated. The bars are the mean number of calbindin+ve neurons ± the standard error of the mean of six mice. The Amh genotype (+/+ or -/-) is shown beneath each bar. (A) Twenty-day-old mice. *1: There was a significant effect of sex (p = 0.001), genotype (p = 0.008) and sex × genotype interaction (p = 0.022, two-way ANOVA). *2: The Amh+/+ males were significantly different to Amh-/- males (p = 0.004) and both female groups (p < 0.002 Amh+/+, p < 0.001 Amh-/-, Student’s t test). (B) Adult mice. *3: There was a significant effect of sex (p < 0.001), genotype (p = 0.002) and sex × genotype interaction (p = 0.003, two-way ANOVA). *4: The Amh+/+ males were significantly different to all other adult groups (p = 0.002 to the Amh-/- males and p < 0.001 to both female groups, Student’s t test). *5: The adult Amh-/- males were also significantly different to both of the adult female groups (p < 0.001 Amh+/+, p < 0.001 Amh-/-, Student’s t test). (C) The bars illustrate the mean change in cell number after 20 days. In two-way ANOVAs of age and genotype, there was a significant effect of age (p = 0.007) and genotype (p < 0.001) for the male mice and a significant effect of age (p < 0.001) for the female mice. The adult mice were significantly different to the corresponding 20-day-old mice (p = 0.037 for the Amh+/+ males, p = 0.035 for the Amh+/+ females and p = 0.017 for the Amh-/- females, Student’s t test). , male; ♀, female.

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