Figure 6
From: Growth hormone exacerbates diabetic renal damage in male but not female rats
Effect of sex on renal cortical MMP-2 and MMP-9 protein abundance in control and diabetic rats treated with and without GH. (A) STZ and STZ + GH treatments significantly decrease MMP-2 levels in female mice compared to control. * P < 0.01 vs. female controls. (B) STZ significantly decreases MMP-2 protein levels in male mice compared to control, and STZ + GH treatment is significantly lower than STZ alone. * P < 0.01 vs. male control, # P < 0.05 vs. male STZ. (C) STZ and STZ + GH treatments significantly decrease female MMP-9 levels than in controls. * P < 0.01 vs. female controls. (D) STZ significantly decreases MMP-9 protein levels in male mice compared to control, and STZ + GH treatment is significantly lower than STZ alone. * P < 0.01 vs. male control, # P < 0.05 vs. male STZ.