Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 4 Sex-specific transcriptional regulators

From: Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood

Gene Name Ihh Klf17 Ybx2 Cdx4 Cux2 Id1 Jazf1 Tox Trim24
Accession Number NM_010544 NM_029416 NM_016875 NM_007674 NM_007804 NM_010495 NM_173406 NM_145711 NM_145076
Sex specificity M M M F F F F F F
Onset of sex specificity 4 wk 8 wk 8 wk 4 wk 4 wk 8 wk 8 wk 4 wk 4 wk
Developmental change in M liver (3, 4 wk to 8 wk) up up up down down* down down down* down
Developmental change in F liver (3, 4 wk to 8 wk) no change no change up no change up no change no change Up up*
Response to HNF4α-knockout down in M down in M - up in M up in M up in M up in F up in M up in F up in M up in F up in M up in F
Response to STAT5-knockout - - down in M no effect up in M - no effect up in M up in M
Response to Hypox down in M down in M - down in F up in M, down in F up in M up in M up in M down in F
Response to continuous GH - - down in M at ≥ 4 day up in M at ≥ 4 day up in M at ≥ 2 day - no effect no effect up in M at ≥ 10 hr
  1. Adult sex-specific genes with a |fold change| > 2 and p < 0.0001 for the male 8 wk vs. female 8 wk microarray comparison and having GO descriptors that contain the words "DNA binding" or "transcription" were identified as potential transcriptional regulators. The transcription factor genes listed in this table were previously found to be altered in expression in response to hypophysectomy [27], STAT5b-deficiency [32], HNF4α-deficiency [24], or treatment with continuous GH [46]. M, male, F, female
  2. * Indicates a gene that displayed a developmental change at 4 wk but not 3 wk
  3. - Indicates no probe for the gene on the microarray platform that was used for the analysis.