Table 4 Sex-specific transcriptional regulators
Gene Name | Ihh | Klf17 | Ybx2 | Cdx4 | Cux2 | Id1 | Jazf1 | Tox | Trim24 |
|---|---|---|---|---|---|---|---|---|---|
Accession Number | NM_010544 | NM_029416 | NM_016875 | NM_007674 | NM_007804 | NM_010495 | NM_173406 | NM_145711 | NM_145076 |
Sex specificity | M | M | M | F | F | F | F | F | F |
Onset of sex specificity | 4 wk | 8 wk | 8 wk | 4 wk | 4 wk | 8 wk | 8 wk | 4 wk | 4 wk |
Developmental change in M liver (3, 4 wk to 8 wk) | up | up | up | down | down* | down | down | down* | down |
Developmental change in F liver (3, 4 wk to 8 wk) | no change | no change | up | no change | up | no change | no change | Up | up* |
Response to HNF4α-knockout | down in M | down in M | - | up in M | up in M | up in M up in F | up in M up in F | up in M up in F | up in M up in F |
Response to STAT5-knockout | - | - | down in M | no effect | up in M | - | no effect | up in M | up in M |
Response to Hypox | down in M | down in M | - | down in F | up in M, down in F | up in M | up in M | up in M | down in F |
Response to continuous GH | - | - | down in M at ≥ 4 day | up in M at ≥ 4 day | up in M at ≥ 2 day | - | no effect | no effect | up in M at ≥ 10 hr |