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Table 3 Genes showing developmental changes are enriched for genes altered by hypophysectomy

From: Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood

A. Background: All genes (22,635) Genes up regulated in male hypophysectomized liver (2,250 genes) Genes down regulated in male hypophysectomized liver (2,202 genes)
  # of overlapping genes Fold enrichment Fisher Test p -value # of overlapping genes Fold enrichment Fisher Test p -value
All genes up regulated in male liver 3-8 wk (1,542 genes) 213 1.39 3.05E-06 306 2.04 2.13E-30
All genes down regulated in male liver 3-8 wk (1,773 genes) 393 2.23 7.12E-47 163 0.95 0.479
B. Background: All genes (22,635) Genes up regulated in female hypophysectomized liver (1,521 genes) Genes down regulated in female hypophysectomized liver (1,535 genes)
  # of overlapping genes Fold enrichment Fisher Test p-value # of overlapping genes Fold enrichment Fisher Test p-value
All genes up regulated in female liver 3-8 wk (1,070 genes) 131 1.82 2.38E-10 151 2.08 2.91E-16
All genes down regulated in female liver 3-8 wk (1,364 genes) 203 2.21 5.87E-24 139 1.50 5.16E-06
  1. Genes identified in the present microarray study were grouped based on their regulation from 3 wk to 8 wk and compared to genes from a previous microarray study [27] grouped by their response to hypophysectomy. Enrichments were calculated as described in Table 2. Total numbers of genes comprising each group are shown in parenthesis. Bold text indicates enrichment with a highly significant p-value (p < 0.0001, Fisher's exact test).