Box and whisker plots representing gene expression patterns in genes clustered by STEM profiles. Boxes represent the 25th to the 75th percentile of gene expression ratios for each of the 7 microarray comparisons indicated below the X-axis. A horizontal line across each box indicates the median expression ratio. The whiskers that extend above and below each box represent the highest and the lowest values. M3, male liver at 3 wk; M4, male liver at 4 wk; M8, male liver at 8 wk; F3, female liver at 3 wk; F4, female liver at 4 wk; and F8, female liver at 8 wk. A. Profile 1 is the largest adult sex-independent (SI) STEM cluster comprised of down regulated genes. On average, these genes are slightly more down regulated from 3 to 8 wk than from 4 to 8 wk in both male and female liver. B. Profile 2 is the largest adult sex-independent STEM cluster comprised of up regulated genes. These genes are slightly more up regulated from 3 to 8 wk than from 4 to 8 wk in both male and female liver. C. Profile 8 is the largest adult male-specific STEM cluster. These genes are up regulated from 3 to 8 wk and from 4 to 8 wk in male liver and to a lesser extent in female liver. D. Profile 11 is the large adult female-specific STEM cluster. These genes are down regulated from 3 to 8 wk and from 4 to 8 wk in male but not female liver.