Figure 3From: Sex-specific mouse liver gene expression: genome-wide analysis of developmental changes from pre-pubertal period to young adulthood Box and whisker plots representing gene expression patterns in genes clustered by STEM profiles. Boxes represent the 25th to the 75th percentile of gene expression ratios for each of the 7 microarray comparisons indicated below the X-axis. A horizontal line across each box indicates the median expression ratio. The whiskers that extend above and below each box represent the highest and the lowest values. M3, male liver at 3 wk; M4, male liver at 4 wk; M8, male liver at 8 wk; F3, female liver at 3 wk; F4, female liver at 4 wk; and F8, female liver at 8 wk. A. Profile 1 is the largest adult sex-independent (SI) STEM cluster comprised of down regulated genes. On average, these genes are slightly more down regulated from 3 to 8 wk than from 4 to 8 wk in both male and female liver. B. Profile 2 is the largest adult sex-independent STEM cluster comprised of up regulated genes. These genes are slightly more up regulated from 3 to 8 wk than from 4 to 8 wk in both male and female liver. C. Profile 8 is the largest adult male-specific STEM cluster. These genes are up regulated from 3 to 8 wk and from 4 to 8 wk in male liver and to a lesser extent in female liver. D. Profile 11 is the large adult female-specific STEM cluster. These genes are down regulated from 3 to 8 wk and from 4 to 8 wk in male but not female liver.Back to article page