MAP and HR after Ang II infusion in GDX four core genotype mice. Shown are the mean ± SEM for MAP (A) and HR (B) two weeks after Ang II infusion at 200 ng/kg/min in the GDX four core genotype; XX-Female (white, n = 9), XY-Female (horizontal stripes, n = 9), XX-Male (diagonal stripes, n = 8) and XY-Male (black, n = 8). Two-Way ANOVA showed that the sex chromosomes account for 16% of the total variance (*p < 0.03 vs. XX, regardless of gonadal sex) on MAP whereas there was no gonadal sex effect (p = 0.58) nor any interaction between the sex chromosomes and gonadal sex (p = 0.90). There was no SCE (p = 0.55) or interaction between the sex chromosomes and gonadal sex (p = 0.13) on HR. Gonadal sex accounted for 31% of the total variance (#p < 0.001 vs female, regardless of sex chromosome complement) in HR. This data is republished from reference .