Figure 12

Generation of the four core genotype. The Sry gene was spontaneously deleted from the Y chromosome (Y^-) and transferred to an autosome resulting in the XY^- Sry male mouse. Breeding XX females with XY^- Sry males produces the four core genotype: XY^- and XX females and XY^- Sry and XXSry males. We refer to XX and XY^- as XX and XY-Females and XXSry and XY^- Sry as XX- and XY-Males throughout the text.