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Figure 11 | Biology of Sex Differences

Figure 11

From: Sex differences in primary hypertension

Figure 11

Effect of gonadectomy on blood pressure in experimental models of hypertension. Top panel, Shown is the difference in blood pressure between ovariectomized (Ovx) and intact (Intact) females in animal models of hypertension including Ang II infusion in C57 mice (C57+Ang II) [38]a, Wistar rats infused with L-NAME (W+L-NAME) [44]c, SD rats treated with deocycorticosterone acetate and HS (SD+DOCA+NaCl) [54]a, DS rats [57]a and the SHR [112]a maintained on a LS and HS diet and the mRen2.Lewis rat [111]c. Bottom panel, Shown is the difference in blood pressure between orchiectomy (Orch) and intact (Intact) males in animal models of hypertension including C57+Ang II [38]a, W+L-NAME [44]c, SD+DOCA+NaCl [54]a, DS maintained on a LS and HS diet [173]a, SHR [146]b and the SPSHR [145]c. §p < 0.05 vs Intact, same sex (see cited references for experimental and statistical details of individual studies). Note, studies measuring MAP by radiotelemetrya were preferentially cited over studies using indwelling cathetersb or those reporting SBP determined by tail plethysmographyc.

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