Skip to main content

Table 5 Release of tumor necrosis factor α in monocyte-derived macrophages (MDMs) obtained from each subgroup of females

From: Oral contraceptives modify DNA methylation and monocyte-derived macrophage function

Subgroup Unstimulated (ng/ml) Lipopolysaccharide (% increase) P value
Fs, n = 76 67.4 (12.1 to 971.8) 2786.7 (323.6 to 29272.3) < 0.001a
FOCs, n = 68 93.8(14.7 to 702.5) 1694.3(476.6 to 15386.7) < 0.001a; < 0.02*
FOCA+, n = 33 90.5 (14.7 to 693.7) 1597.9 (507.3 to 10314.1) < 0.001a
FOCA-, n = 35 88.6 (15.8 to 702.5) 1977.8 (476.6 to 15386.7) < 0.001a
  1. Data are medians and ranges; n indicates the number of samples used to calculate the statistics.
  2. aIndicates the P value between unstimulated and stimulated MDMs.
  3. *P value between FOCs and Fs.
  4. FOCA+/FOCA- = FOCs further stratified as a function of androgenic (FOCA+) and non-androgenic (FOCA-) properties of progestins; FOCs = women treated with OCs for at least 3 months; Fs = women who had not used OCs for at least 3 months to ensure a sufficient washout period; OC = oral contraceptive.