Table 3 Gaps in knowledge on the contributions of mechanical factors to sex differences in knee OA
From: Mechanical contributors to sex differences in idiopathic knee osteoarthritis
Limb Alignment | Â |
|---|---|
1. | Are there sex differences in the prevalence of unilateral and bilateral limb alignment? |
2. | How does limb alignment change across the lifespan for men and women? |
3. | Are there sex differences in the prevalence of limb malalignment between obese men and obese women? |
Muscle Function | Â |
1. | Can strength training attenuate the incidence and progression of knee OA and is the intervention more or less effective in women? |
2. | Do observed sex differences in muscle function during walking among individuals with knee OA contribute to either the development or worsening of the disease? |
3. | What are the magnitudes of the cartilage stresses associated with differences in the mechanical output of lower limb muscles observed in men and women with knee OA during walking? |
Obesity | Â |
1. | Does the differential influence of fat and muscle mass on the development and progression of knee OA differ for men and women? |
2. | Do circulating levels of inflammatory markers predict the sex difference in the prevalence of knee OA among older adults? |
3. | Do meniscal lesions occur more frequently in men or women? |