Figure 1

Male mice develop more severe myocarditis than female mice despite equivalent viral titers. Figure 1A. Male mice have higher levels of inflammation than female mice at the Day 6 timepoint (p=<0.001). Histology was scored blindly on a 1-4 scale by an experienced member of the lab. Figure 1C show representative micrographs, note that the black arrows point to areas of inflammation. Figure 1B shows cardiac viral titers as log10 PFU/gram. Despite differences in histology score, no significant difference was observed in viral load between male and female mice at either Day 0, 3 or 6 post infection. Numbers of mice used in this experiment were as follows: Males D6=7, D3=7; Female D6=14, D3=9).