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Table 3 Male studies of cognition & behavior in mouse models of AD

From: Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition?

Hormone/ Regimen

Manipulation

Timing, Route, Dose

Comparison A

Cognition & Behavioral Measure and Ref.

AD Tg Model

Hormone Depletion

Gnx 3 mos

N/A

Intact vs Gnx

Gnx ↓ SAB (Y-maze) [177]

3xTg-AD

Flutamide B

Postnatal d1-20

IP injection of flutamide (50 mg/kg/d)

Intact: Veh vs Flutamide

Flutamide ↓ SAB (Y-maze) [116]

3xTg-AD

Genetic Knockdown of Aromatase C

None

N/A

Intact: Aromatase+/− vs Aromatase+/+

Aromatase+/− ↑ spatial memory (Hole-board) [178]

APP23

DHT

Gnx 3 mos

Immediate s.c. DHT (10 mg) 90+d

Gnx: Veh vs DHT

DHT ↑ SAB (Y-maze) [177]

3xTg-AD

  1. Symbols: ↑=increase, ↓=decrease, ↔=no change.
  2. Abbreviations: Tg=transgenic, mos=months, d=day, Gnx=gonadectomy, SAB=spontaneous alternating behavior (thought to reflect working memory), IP=intraperitoneal, Veh=Vehicle, DHT=dihydrotestosterone.
  3. A, All comparisons are between groups of AD Tg mice.
  4. B, Flutamide is an androgen receptor antagonist.
  5. C, Males with aromatase knockdown have increased endogenous testosterone levels, and decreased brain and sera estradiol levels.
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Biology of Sex Differences

ISSN: 2042-6410

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