Figure 5From: Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition? Research strategy for studying males in mouse models of AD. To determine how reproductive aging alters AD-related measures in males, an appropriate strategy is comparing gonadectomized to intact mice. To determine whether hormone replacement alters AD-related measures in males, an appropriate strategy is comparing vehicle- versus hormone-treated mice that have all undergone gonadectomy to simulate human reproductive aging.Back to article page