Figure 3From: Sex and gonadal hormones in mouse models of Alzheimer’s disease: what is relevant to the human condition? Research strategy for studying sex differences in mouse models of AD. Gonadectomy of both male and female mice simulates gonadal steroid depletion that occurs in human reproductive aging. It also enables a direct comparison between the sexes that is less confounded by differential, activational effects of gonadal hormones in the male versus female brain.Back to article page