Sexually dimorphic effects of oxytocin receptor gene (OXTR) variants on Harm Avoidance

Table 1 TCI temperament scores (mean ±SD) for 99 men and women, stratified by OXTR genotype

*OXTR* genotype ^a	NS	HA	RD	PS
male T-allele carriers (N=27)	20.0 ±6.1	12.7 ±5.4	15.0 ±3.7	4.4 ±2.1
female T-allele carriers (N=29)	22.3 ±6.1	16.4 ±5.4	16.5 ±2.9	3.4 ±1.9
male non-carriers (N=20)	21.5 ±6.1	11.9 ±4.5	16.5 ±3.6	4.1 ±1.8
female non-carriers (N=21)	22.8 ±4.4	14.5 ±5.0	15.4 ±3.2	4.0 ±1.9
effects of predictor variables
F (2,94) _{[sex rs237900]}	1.615	5.460	0.215	1.396
p _{[sex rs237900]}	0.204	0.005	0.807	0.253
p _[corrected]	1.000	0.046	1.000	1.000
F (3,93) _{[including sex*rs237900]}	1.144	3.693	1.407	1.327
p _{[including sex*rs237900]}	0.335	0.014	0.246	0.270

When sex is controlled for and a recessive mode of inheritance is assumed, rs237900 predicts Harm Avoidance in additive and multiplicative regression models.
significance tests refer to log-transformed TCI scores.
^a results are shown for rs237900, 2 unreadable ABI trace files.
NS=Novelty Seeking, HA=Harm Avoidance, RD=Reward Dependence, PS=Persistence.

ISSN: 2042-6410