Table 4 Associations of Ki67 expression with clinicopathological factors in the full cohort, women and men
Ki67 expression | All | Women | Men | ||||||
|---|---|---|---|---|---|---|---|---|---|
Low | High | P | Low | High | P | Low | High | P | |
n(%) | 159 (77.2) | 47 (22.8) | 77 (58.3) | 26 (19.7) | 82 (79.6) | 21 (20.4) | |||
Age | |||||||||
Continuous | 68 (46–81) | 70 (47–83) | 0.233 | 66 (46–81) | 69 (47–83) | 0.366 | 70 (53–80) | 72 (55–80) | 0.317 |
Location | |||||||||
Dorsal trunk | 43 (28.1) | 10 (21.3) | 0.120 | 13 (17.3) | 3 (11.5) | 0.135 | 30 (38.5) | 7 (33.3) | 0.520 |
Frontal trunk | 19 (12.4) | 4 (8.5) | 7 (9.3) | 1 (3.8) | 12 (15.4) | 3 (14.3) | |||
Arms | 27 (17.6) | 9 (19.1) | 17 (22.7) | 6 (23.1) | 10 (12.8) | 3 (14.3) | |||
Legs | 44 (28.8) | 27.7) | 33 (44.0) | 11 (42.3) | 1 (14.1) | 2 (9.5) | |||
Head and neck | 20 (13.1) | 11 (23.4) | 5 (6.7) | 5 (19.2) | 15 (19.2) | 6 (28.6) | |||
Unknown | 6 | 0 | 2 | 0 | 4 | 0 | |||
Histological subtype | |||||||||
SSM, LMM, Other | 130 (82.3) | 24 (51.1) | <0.001 | 63 (81.8) | 14 (53.8) | 0.004 | 67 (82.7) | 10 (47.6) | 0.001 |
NMM | 28 (17.7) | 23 (48.9) | 14 (18.2) | 12 (46.2) | 14 (17.3) | 11 (52.4) | |||
Unknown | 1 | 0 | 0 | 0 | |||||
Breslow thickness | |||||||||
<=1 mm | 107 (68.2) | 15 (31.9) | <0.001 | 54 (71.1) | 9 (34.6) | 0.001 | 53 (65.4) | 6 (28.6) | 0.002 |
>1 mm | 50 (31.8) | 32 (68.1) | 22 (28.9) | 17 (65.4) | 28 (34.6) | 15 (71.4) | |||
Unknown | 2 | 0 | 0 | 0 | 1 | 0 | |||
Clark level | |||||||||
II-III | 128 (81.5) | 28 (60.9) | 0.004 | 64 (84.2) | 14 (56.0) | 0.004 | 64 (79.0) | 14 (66.7) | 0.237 |
IV-V | 29 (18.5) | 18 (39.1) | 12 (15.8) | 11 (44.0) | 17 (21.0) | 7 (33.3) | |||
Unknown | 2 | 1 | 2 | 1 | 1 | 0 | |||
Ulceration | |||||||||
No | 142 (89.9) | 31 (66.0) | <0.001 | 70 (90.9) | 15 (57.7) | <0.001 | 72 (88.9) | 16 (76.2) | 0.134 |
Yes | 16 (10.1) | 16 (34.0) | 7 (9.1) | 11 (42.3) | 9 (11.1) | 5 (23.8) | |||
Unknown | 1 | 0 | 0 | 0 | 1 | 0 | |||
Clinical stage | |||||||||
1 | 121 (76.1) | 20 (42.6) | <0.001 | 60 (88.2) | 13 (81.2) | 0.459 | 61 (91.0) | 7 (43.8) | <0.001 |
2-4 | 14 (8.8) | 12 (25.5) | 8 (11.8) | 3 (18.8) | 6 (9.0) | 9 (56.2) | |||
Unknown | 24 | 15 | 9 | 10 | 15 | 5 | |||
Vascular invasion | |||||||||
No | 146 (91.8) | 46 (97.9) | 0.149 | 73 (94.8) | 26 (100.0) | 0.238 | 73 (89.0) | 20 (95.2) | 0.393 |
Yes | 13 (8.2) | 1 (2.1) | 4 (5.2) | 0 | 9 (11.0) | 1 (4.8) | |||
Unknown | 0 | 0 | 0 | 0 | 0 | 0 | |||
Mitotic count | |||||||||
0/mm2 | 88 (55.3) | 13 (27.7) | 0.001 | 42 (54.5) | 7 (26.9) | 0.015 | 46 (56.1) | 6 (28.6) | 0.025 |
> = 1/mm2 | 71 (44.7) | 34 (72.3) | 35 (45.5) | 19 (73.1) | 36 (43.9) | 15 (71.4) | |||
Unknown | 0 | 0 | 0 | 0 | 0 | 0 | |||
Lymphocytic infiltrate | |||||||||
None-mild | 42 (26.4) | 14 (29.8) | 0.667 | 20 (26.0) | 08 (30.8) | 0.636 | 22 (27.2) | 6 (28.6) | 0.898 |
Moderate-brisk | 116 (73.0) | 33 (70.2) | 57 (74.0) | 18 (69.2) | 59 (72.8) | 15 (71.4) | |||
Unknown | 1 | 0 | 0 | 0 | 1 | 0 | |||