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Table 4 Associations of Ki67 expression with clinicopathological factors in the full cohort, women and men

From: Modifying effect of gender on the prognostic value of clinicopathological factors and Ki67 expression in melanoma: a population-based cohort study

Ki67 expression All Women Men
Low High P Low High P Low High P
n(%) 159 (77.2) 47 (22.8)   77 (58.3) 26 (19.7)   82 (79.6) 21 (20.4)  
Age          
Continuous 68 (46–81) 70 (47–83) 0.233 66 (46–81) 69 (47–83) 0.366 70 (53–80) 72 (55–80) 0.317
Location          
Dorsal trunk 43 (28.1) 10 (21.3) 0.120 13 (17.3) 3 (11.5) 0.135 30 (38.5) 7 (33.3) 0.520
Frontal trunk 19 (12.4) 4 (8.5)   7 (9.3) 1 (3.8)   12 (15.4) 3 (14.3)  
Arms 27 (17.6) 9 (19.1)   17 (22.7) 6 (23.1)   10 (12.8) 3 (14.3)  
Legs 44 (28.8) 27.7)   33 (44.0) 11 (42.3)   1 (14.1) 2 (9.5)  
Head and neck 20 (13.1) 11 (23.4)   5 (6.7) 5 (19.2)   15 (19.2) 6 (28.6)  
Unknown 6 0   2 0   4 0  
Histological subtype          
SSM, LMM, Other 130 (82.3) 24 (51.1) <0.001 63 (81.8) 14 (53.8) 0.004 67 (82.7) 10 (47.6) 0.001
NMM 28 (17.7) 23 (48.9)   14 (18.2) 12 (46.2)   14 (17.3) 11 (52.4)  
Unknown 1 0   0 0     
Breslow thickness          
<=1 mm 107 (68.2) 15 (31.9) <0.001 54 (71.1) 9 (34.6) 0.001 53 (65.4) 6 (28.6) 0.002
>1 mm 50 (31.8) 32 (68.1)   22 (28.9) 17 (65.4)   28 (34.6) 15 (71.4)  
Unknown 2 0   0 0   1 0  
Clark level          
II-III 128 (81.5) 28 (60.9) 0.004 64 (84.2) 14 (56.0) 0.004 64 (79.0) 14 (66.7) 0.237
IV-V 29 (18.5) 18 (39.1)   12 (15.8) 11 (44.0)   17 (21.0) 7 (33.3)  
Unknown 2 1   2 1   1 0  
Ulceration          
No 142 (89.9) 31 (66.0) <0.001 70 (90.9) 15 (57.7) <0.001 72 (88.9) 16 (76.2) 0.134
Yes 16 (10.1) 16 (34.0)   7 (9.1) 11 (42.3)   9 (11.1) 5 (23.8)  
Unknown 1 0   0 0   1 0  
Clinical stage          
1 121 (76.1) 20 (42.6) <0.001 60 (88.2) 13 (81.2) 0.459 61 (91.0) 7 (43.8) <0.001
2-4 14 (8.8) 12 (25.5)   8 (11.8) 3 (18.8)   6 (9.0) 9 (56.2)  
Unknown 24 15   9 10   15 5  
Vascular invasion          
No 146 (91.8) 46 (97.9) 0.149 73 (94.8) 26 (100.0) 0.238 73 (89.0) 20 (95.2) 0.393
Yes 13 (8.2) 1 (2.1)   4 (5.2) 0   9 (11.0) 1 (4.8)  
Unknown 0 0   0 0   0 0  
Mitotic count          
0/mm2 88 (55.3) 13 (27.7) 0.001 42 (54.5) 7 (26.9) 0.015 46 (56.1) 6 (28.6) 0.025
> = 1/mm2 71 (44.7) 34 (72.3)   35 (45.5) 19 (73.1)   36 (43.9) 15 (71.4)  
Unknown 0 0   0 0   0 0  
Lymphocytic infiltrate          
None-mild 42 (26.4) 14 (29.8) 0.667 20 (26.0) 08 (30.8) 0.636 22 (27.2) 6 (28.6) 0.898
Moderate-brisk 116 (73.0) 33 (70.2)   57 (74.0) 18 (69.2)   59 (72.8) 15 (71.4)  
Unknown 1 0   0 0   1 0  
  1. P-values refer to Mann Whitney U test for comparison of means and Chi square test for X × 2 tables. The categories marked as unknown were not included in the analyses.
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