Overall
|
Univariable
|
Multivariable
|
---|
All HR(95%CI)
|
Women HR(95%CI)
|
Men HR(95%CI)
|
All HR(95%CI)
|
Women HR(95%CI)
|
Men HR(95%CI)
|
---|
Age
| | | | | | |
Continuous
|
1.09 (1.04-1.13)
|
1.08 (1.02-1.15)
|
1.08 (1.02--1.14)
|
1.07 (1.02-1.13)
|
1.09 (1.02-1.16)
|
1.10 (1.02-1.18)
|
Sex
| | | | | | |
Women
|
1.00
|
-
|
-
|
1.00
|
-
|
-
|
Men
|
2.60 (1.47-4.61)
|
-
|
-
|
1.89 (0.95-3.79)
|
-
|
-
|
Histological subtype
| | | | | | |
LMM + SSM
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
NMM
|
3.86 (2.21-6.74)
|
3.93 (1.54-10.03)
|
4.17 (2.06-8.44)
|
2.73 (1.38-5.40)
|
3.35 (1.25-8.95)
|
2.88 (1.21-6.84)
|
Breslow thickness
| | | | | | |
<=1 mm
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
> 1 mm
|
4.17 (2.38-7.32)
|
4.53 (1.74-11.79)
|
3.66 (1.83-7.34)
|
0.73 (0.16-3.42)
|
0.56 (0.04-7.58)
|
0.58 (0.08-4.28)
|
Clark level
| | | | | | |
II-III
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
IV-V
|
2.27 (1.28-4.05)
|
1.87 (0.66-5.25)
|
2.22 (1.11-4.44)
|
0.84 (0.36-1.92)
|
0.53 (0.15-1.88)
|
1.10 (0.35-3.41)
|
Ulceration
| | | | | | |
No
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
Yes
|
6.29 (4.46-11.45)
|
5.83 (2.14-15.85)
|
7.33 (3.44-15.62)
|
2.63 (1.19-5.83)
|
1.01 (0.18-5.76)
|
3.34 (1.30-8.60)
|
Clinical stage
| | | | | | |
1
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
2-4
|
6.48 (3.05-13.73)
|
5.48 (1.43-21.04)
|
6.34 (2.49-16.14)
|
1.71 (0.57-5.08)
|
2.54 (0.59-10.89)
|
0.59 (0.11-3.29)
|
Vascular invasion
| | | | | | |
No
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
Yes
|
4.89 (2.38-4.08)
|
13.43 (2.84-63.50)
|
2.82 (1.23-6.50)
|
4.54 (1.90-10.84)
|
19.95 (3.63-109.75)
|
4.89 (1.66-14.41)
|
Mitotic count
| | | | | | |
0/mm2
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
> = 1/mm2
|
2.96 (1.66-5.28)
|
3.54 (1.26-9.96)
|
2.86 (1.41-5.82)
|
1.49 (0.65-3.40)
|
1.63 (0.34-7.81)
|
1.34 (0.44-4.07)
|
Lymphocytic infiltrate
| | | | | | |
None-mild
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
Moderate-brisk
|
0.46 (0.26-0.79)
|
0.53 (0.17-1.09)
|
0.45 (0.22-0.90)
|
0.66 (0.35-1.25)
|
1.03 (0.30-3.49)
|
0.60 (0.27-1.35)
|
Ki67 expression
| | | | | | |
0-25%
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
1.00
|
>25%
|
1.97 (1.06-3.64)
|
1.79 (0.66-4.87)
|
2.38 (1.09-5.22)
|
1.55 (0.73-3.30)
|
1.46 (0.34-6.14)
|
2.65 (1.08-6.52)
|
- LMM = lentigo maligna melanoma, SSM = superficial spreading melanoma, NMM = nodular malignant melanoma.