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Table 3 Univariable and multivariable analyses of factors associated with overall survival in the full cohort, women and men

From: Modifying effect of gender on the prognostic value of clinicopathological factors and Ki67 expression in melanoma: a population-based cohort study

Overall Univariable Multivariable
All HR(95%CI) Women HR(95%CI) Men HR(95%CI) All HR(95%CI) Women HR(95%CI) Men HR(95%CI)
Age       
Continuous 1.09 (1.04-1.13) 1.08 (1.02-1.15) 1.08 (1.02--1.14) 1.07 (1.02-1.13) 1.09 (1.02-1.16) 1.10 (1.02-1.18)
Sex       
Women 1.00 - - 1.00 - -
Men 2.60 (1.47-4.61) - - 1.89 (0.95-3.79) - -
Histological subtype       
LMM + SSM 1.00 1.00 1.00 1.00 1.00 1.00
NMM 3.86 (2.21-6.74) 3.93 (1.54-10.03) 4.17 (2.06-8.44) 2.73 (1.38-5.40) 3.35 (1.25-8.95) 2.88 (1.21-6.84)
Breslow thickness       
<=1 mm 1.00 1.00 1.00 1.00 1.00 1.00
> 1 mm 4.17 (2.38-7.32) 4.53 (1.74-11.79) 3.66 (1.83-7.34) 0.73 (0.16-3.42) 0.56 (0.04-7.58) 0.58 (0.08-4.28)
Clark level       
II-III 1.00 1.00 1.00 1.00 1.00 1.00
IV-V 2.27 (1.28-4.05) 1.87 (0.66-5.25) 2.22 (1.11-4.44) 0.84 (0.36-1.92) 0.53 (0.15-1.88) 1.10 (0.35-3.41)
Ulceration       
No 1.00 1.00 1.00 1.00 1.00 1.00
Yes 6.29 (4.46-11.45) 5.83 (2.14-15.85) 7.33 (3.44-15.62) 2.63 (1.19-5.83) 1.01 (0.18-5.76) 3.34 (1.30-8.60)
Clinical stage       
1 1.00 1.00 1.00 1.00 1.00 1.00
2-4 6.48 (3.05-13.73) 5.48 (1.43-21.04) 6.34 (2.49-16.14) 1.71 (0.57-5.08) 2.54 (0.59-10.89) 0.59 (0.11-3.29)
Vascular invasion       
No 1.00 1.00 1.00 1.00 1.00 1.00
Yes 4.89 (2.38-4.08) 13.43 (2.84-63.50) 2.82 (1.23-6.50) 4.54 (1.90-10.84) 19.95 (3.63-109.75) 4.89 (1.66-14.41)
Mitotic count       
0/mm2 1.00 1.00 1.00 1.00 1.00 1.00
> = 1/mm2 2.96 (1.66-5.28) 3.54 (1.26-9.96) 2.86 (1.41-5.82) 1.49 (0.65-3.40) 1.63 (0.34-7.81) 1.34 (0.44-4.07)
Lymphocytic infiltrate       
None-mild 1.00 1.00 1.00 1.00 1.00 1.00
Moderate-brisk 0.46 (0.26-0.79) 0.53 (0.17-1.09) 0.45 (0.22-0.90) 0.66 (0.35-1.25) 1.03 (0.30-3.49) 0.60 (0.27-1.35)
Ki67 expression       
0-25% 1.00 1.00 1.00 1.00 1.00 1.00
>25% 1.97 (1.06-3.64) 1.79 (0.66-4.87) 2.38 (1.09-5.22) 1.55 (0.73-3.30) 1.46 (0.34-6.14) 2.65 (1.08-6.52)
  1. LMM = lentigo maligna melanoma, SSM = superficial spreading melanoma, NMM = nodular malignant melanoma.
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Biology of Sex Differences

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