Table 3 Univariable and multivariable analyses of factors associated with overall survival in the full cohort, women and men
Overall | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
All HR(95%CI) | Women HR(95%CI) | Men HR(95%CI) | All HR(95%CI) | Women HR(95%CI) | Men HR(95%CI) | |
Age | ||||||
Continuous | 1.09 (1.04-1.13) | 1.08 (1.02-1.15) | 1.08 (1.02--1.14) | 1.07 (1.02-1.13) | 1.09 (1.02-1.16) | 1.10 (1.02-1.18) |
Sex | ||||||
Women | 1.00 | - | - | 1.00 | - | - |
Men | 2.60 (1.47-4.61) | - | - | 1.89 (0.95-3.79) | - | - |
Histological subtype | ||||||
LMM + SSM | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
NMM | 3.86 (2.21-6.74) | 3.93 (1.54-10.03) | 4.17 (2.06-8.44) | 2.73 (1.38-5.40) | 3.35 (1.25-8.95) | 2.88 (1.21-6.84) |
Breslow thickness | ||||||
<=1 mm | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
> 1 mm | 4.17 (2.38-7.32) | 4.53 (1.74-11.79) | 3.66 (1.83-7.34) | 0.73 (0.16-3.42) | 0.56 (0.04-7.58) | 0.58 (0.08-4.28) |
Clark level | ||||||
II-III | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
IV-V | 2.27 (1.28-4.05) | 1.87 (0.66-5.25) | 2.22 (1.11-4.44) | 0.84 (0.36-1.92) | 0.53 (0.15-1.88) | 1.10 (0.35-3.41) |
Ulceration | ||||||
No | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Yes | 6.29 (4.46-11.45) | 5.83 (2.14-15.85) | 7.33 (3.44-15.62) | 2.63 (1.19-5.83) | 1.01 (0.18-5.76) | 3.34 (1.30-8.60) |
Clinical stage | ||||||
1 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
2-4 | 6.48 (3.05-13.73) | 5.48 (1.43-21.04) | 6.34 (2.49-16.14) | 1.71 (0.57-5.08) | 2.54 (0.59-10.89) | 0.59 (0.11-3.29) |
Vascular invasion | ||||||
No | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Yes | 4.89 (2.38-4.08) | 13.43 (2.84-63.50) | 2.82 (1.23-6.50) | 4.54 (1.90-10.84) | 19.95 (3.63-109.75) | 4.89 (1.66-14.41) |
Mitotic count | ||||||
0/mm2 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
> = 1/mm2 | 2.96 (1.66-5.28) | 3.54 (1.26-9.96) | 2.86 (1.41-5.82) | 1.49 (0.65-3.40) | 1.63 (0.34-7.81) | 1.34 (0.44-4.07) |
Lymphocytic infiltrate | ||||||
None-mild | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
Moderate-brisk | 0.46 (0.26-0.79) | 0.53 (0.17-1.09) | 0.45 (0.22-0.90) | 0.66 (0.35-1.25) | 1.03 (0.30-3.49) | 0.60 (0.27-1.35) |
Ki67 expression | ||||||
0-25% | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
>25% | 1.97 (1.06-3.64) | 1.79 (0.66-4.87) | 2.38 (1.09-5.22) | 1.55 (0.73-3.30) | 1.46 (0.34-6.14) | 2.65 (1.08-6.52) |