Table 1 Single nucleotide polymorphisms (SNPs) associated with fat distribution in genome-wide association studies
From: Sex differences in human adipose tissues – the biology of pear shape
SNP | Nearby gene | Associated with | Significant in men | Significant in women | Significant sex difference |
|---|---|---|---|---|---|
rs9491696 | RSPO3 (R-spondin 3) | WHR | Yes | Yes | Yes |
rs6905288 | VEGFA (vascular endothelial growth factor A) | WHR | Yes | Yes | Yes |
rs2605100 | LYPLAL1 (lysophospholipase-like protein 1) | WHR | No | Yes | Yes |
rs4846567 | WHR | No | Yes | Yes | |
rs718314 | ITPR2 (inositol 1,4,5-triphosphate receptor 2) – SSPN (sarcospan) | WHR | Yes | Yes | Yes |
rs1443512 | HOXC13 (homeobox C13) | WHR | Yes | Yes | Yes |
rs4823006 | ZNRF3 (zinc and ring finger 3) – KREMEN1 (kringle containing transmembrane protein 1) | WHR | Yes | Yes | Yes |
rs10195252 | GRB14 (growth factor receptor-bound protein 14) | WHR | Borderline | Yes | Yes |
rs6795735 | ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif, 9) | WHR | Borderline | Yes | Yes |
rs984222 | TBX15 (T-box 15) – WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial) | WHR | Yes | Yes | No |
rs1055144 | NFE2L3 [nuclear factor (erythroid-derived 2)-like 3] | WHR | Yes | Yes | No |
rs1011731 | DNM3 (dynamin 3) – PIGC (phosphatidylinositol glycan anchor biosynthesis, class C) | WHR | Yes | Yes | No |
rs1294421 | LY86 (lymphocyte antigen 86) | WHR | Yes | Yes | No |
rs6784615 | NISCH (nischarin) – STAB1 (stabilin 1) | WHR | Yes | Yes | No |
rs6861681 | CPEB4 (cytoplasmic polyadenylation element binding protein 4) | WHR | Yes | Yes | No |
rs987237 | TFAP2B (transcription factor activating enhancer-binding protein 2 beta) | WC | Yes | Yes | No |
rs7826222 | MSRA (methionine sulfoxide reductase A) | WC | Yes | Yes | No |