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Table 1 Single nucleotide polymorphisms (SNPs) associated with fat distribution in genome-wide association studies

From: Sex differences in human adipose tissues – the biology of pear shape

SNP Nearby gene Associated with Significant in men Significant in women Significant sex difference
rs9491696 RSPO3 (R-spondin 3) WHR Yes Yes Yes
rs6905288 VEGFA (vascular endothelial growth factor A) WHR Yes Yes Yes
rs2605100 LYPLAL1 (lysophospholipase-like protein 1) WHR No Yes Yes
rs4846567 WHR No Yes Yes
rs718314 ITPR2 (inositol 1,4,5-triphosphate receptor 2) – SSPN (sarcospan) WHR Yes Yes Yes
rs1443512 HOXC13 (homeobox C13) WHR Yes Yes Yes
rs4823006 ZNRF3 (zinc and ring finger 3) – KREMEN1 (kringle containing transmembrane protein 1) WHR Yes Yes Yes
rs10195252 GRB14 (growth factor receptor-bound protein 14) WHR Borderline Yes Yes
rs6795735 ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif, 9) WHR Borderline Yes Yes
rs984222 TBX15 (T-box 15) – WARS2 (tryptophanyl tRNA synthetase 2, mitochondrial) WHR Yes Yes No
rs1055144 NFE2L3 [nuclear factor (erythroid-derived 2)-like 3] WHR Yes Yes No
rs1011731 DNM3 (dynamin 3) – PIGC (phosphatidylinositol glycan anchor biosynthesis, class C) WHR Yes Yes No
rs1294421 LY86 (lymphocyte antigen 86) WHR Yes Yes No
rs6784615 NISCH (nischarin) – STAB1 (stabilin 1) WHR Yes Yes No
rs6861681 CPEB4 (cytoplasmic polyadenylation element binding protein 4) WHR Yes Yes No
rs987237 TFAP2B (transcription factor activating enhancer-binding protein 2 beta) WC Yes Yes No
rs7826222 MSRA (methionine sulfoxide reductase A) WC Yes Yes No
  1. WHR waist-to-hip ratio, WC waist circumference.