From: Sexually dimorphic effect of aging on skeletal muscle protein synthesis
Time (min) | Concentration | Enrichment | ||||||
---|---|---|---|---|---|---|---|---|
 | (μM) | Muscle protein bound TTR | Muscle free TTR | Plasma TTR | ||||
 | Young | Old | Young | Old | Young | Old | Young | Old |
Basal conditions | Â | Â | Â | Â | Â | Â | ||
60 | 59 ± 8 | 64 ± 9 | 0.000033 ± 0.000007 | 0.000101 ± 0.000026 | 0.0488 ± 0.0037 | 0.0545 ± 0.0044 | 0.0921 ± 0.0055 | 0.0929 ± 0.0066 |
90 | 48 ± 6 | 67 ± 8 | --- | --- | --- | --- | 0.1030 ± 0.0077 | 0.0993 ± 0.0090 |
120 | 58 ± 9 | 63 ± 8 | --- | --- | --- | --- | 0.1032 ± 0.0056 | 0.1119 ± 0.0093 |
150 | 53 ± 9 | 61 ± 9 | --- | --- | --- | --- | 0.1118 ± 0.0119 | 0.1130 ± 0.0067 |
180 | 56 ± 10 | 63 ± 9 | --- | --- | --- | --- | 0.1088 ± 0.0034 | 0.1129 ± 0.0056 |
210 | 60 ± 7 | 66 ± 8 | --- | --- | --- | --- | 0.1093 ± 0.0031 | 0.1155 ± 0.0078 |
240 | 59 ± 8 | 64 ± 9 | 0.000099 ± 0.000009 | 0.000186 ± 0.000029 | 0.0589 ± 0.0027 | 0.0686 ± 0.0048 | 0.1065 ± 0.0032 | 0.1194 ± 0.0079 |
Δ (240 – 60 min) | 0.000067 ± 0.000009 | 0.000085 ± 0.000013 |  |  |  |  | ||
Mean | 56 ± 7 | 64 ± 8 |  |  | 0.0539 ± 0.0028 | 0.0615 ± 0.0041 | 0.1050 ± 0.0051 | 0.1093 ± 0.0071 |
Hyperinsulinemic-hyperaminoacidemic clamp | Â | Â | Â | Â | Â | |||
270 | 93 ± 14 | 97 ± 10 | --- | --- | --- | --- | 0.0969 ± 0.0031 | 0.1108 ± 0.0045 |
300 | 88 ± 12 | 97 ± 10 | --- | --- | --- | --- | 0.0958 ± 0.0034 | 0.1028 ± 0.0042 |
330 | 116 ± 18 | 107 ± 14 | --- | --- | --- | --- | 0.0942 ± 0.0022 | 0.1005 ± 0.0050 |
360 | 85 ± 10 | 121 ± 14 | --- | --- | --- | --- | 0.0950 ± 0.0025 | 0.1000 ± 0.0044 |
390 | 98 ± 12 | 128 ± 16 | --- | --- | --- | --- | 0.0937 ± 0.0013 | 0.1021 ± 0.0055 |
420 | 108 ± 14 | 116 ± 17 | 0.000235 ± 0.000023 | 0.000310 ± 0.000038 | 0.0719 ± 0.0030 | 0.0806 ± 0.0033 | 0.0960 ± 0.0019 | 0.0952 ± 0.0055 |
Δ (420 – 240 min) | 0.000136 ± 0.000015 | 0.000124 ± 0.000020 |  |  |  |  | ||
Mean | 98 ± 12 | 111 ± 12 |  |  | 0.0654 ± 0.0027 | 0.0746 ± 0.0038 | 0.0953 ± 0.0021 | 0.1019 ± 0.0043 |