Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation

Table 3 Passive structural parameters of the SHR and WKY treatment groups^a

Treatment	Strain	CONT	CAST	CAST + T
Passive diameter (μm)	SHR	305.4 ± 22.9 (n = 9)	285.7 ± 14.5 (n = 12)	++274.3 ± 6.4 (n = 10)
	WKY	352.8 ± 26.0 (n = 8)	301.9 ± 10.9 (n = 8)	309.6 ± 10.1 (n = 14)
Wall thickness (μm)	SHR	*34.9 ± 2.5 (n = 9)	28.4 ± 2.3 (n = 12)	31.7 ± 3.4 (n = 10)
	WKY	24.1 ± 3.8 (n = 8)	22.2 ± 3.5 (n = 8)	23.9 ± 2.7 (n = 10)
Wall-to-lumen ratio	SHR	*0.117 ± 0.009 (n = 9)	+0.102 ± 0.009 (n = 12)	++0.124 ± 0.014 (n = 10)
	WKY	0.070 ± 0.001 (n = 8)	0.070 ± 0.010 (n = 8)	0.080 ± 0.010 (n = 12)

^aCAST, castrate; CAST + T, castrate plus testosterone; CONT, control; SHR: spontaneously hypertensive rat; T: testosterone; WKY: Wistar Kyoto. Data are means ± SEM. *P < 0.05 for SHR CONT vs WKY CONT. +^† P < 0.05 for SHR CAST vs WKY CAST.++ ^‡ P < 0.05 for SHR CAST + T vs WKY CAST + T.

ISSN: 2042-6410