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Table 2 Effective concentration needed to constrict to 50% of total diameter with phenylephrine in SHR and WKY treatment groupsa

From: Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation

Treatment Strain CONT CAST CAST + T
EC50 SHR 830 ± 36 nM (n = 10) 827 ± 60 nM (n = 6) 1,570 ± 433 nM (n = 6)**
  WKY 844 ± 45 nM (n = 10) 734 ± 66 nM (n = 6)* 740 ± 41 nM (n = 6)*
  1. aCAST, castrate; CAST + T, castrate plus testosterone; CONT, control; EC50, effective concentration needed to constrict to 50% of total diameter; SHR, spontaneously hypertensive rat; WKY: Wistar Kyoto. Data are means ± SEM. SHR CAST + T was significantly higher than SHR CONT (**P < 0.01). WKY CONT was significantly higher than CAST (*P < 0.05).