Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation

Table 1 SHR and WKY plasma testosterone and plasma norepinephrine levels by treatment group^a

Treatment	Strain	CONT	CAST	CAST + T
Testosterone (ng/ml)	SHR	1.88 ± 0.52	0.05 ± 0.60	12.9 ± 0.70
	WKY	1.08 ± 0.52	0.04 ± 0.70	11.0 ± 0.78
Norepinephrine (pg/ml)	SHR	970.5 ± 88.4***	481.5 ± 50.4**	762.2 ± 53.8*
	WKY	569.5 ± 28.1	415.5 ± 97.3	644.9 ± 74.6

^aCAST, castrate; CAST + T, castrate plus testosterone; CONT, control; NE, norepinephrine; SHR: spontaneously hypertensive rat; T: testosterone; WKY: Wistar Kyoto. Data are means ± SEM. Plasma T was unaltered between SHR and WKY T-manipulated groups. Plasma NE was significantly higher in SHR CONT males than in WKY CONT males (***P < 0.001). Plasma NE was decreased in SHR CAST compared to CONT (**P < 0.01) and increased compared to CAST + T (*P < 0.05).

ISSN: 2042-6410