Cyclin D1 expression | Univariate | Multivariate |
---|
|
HR (95%CI)
|
n (events)
|
P
|
P
a
|
HR (95%CI)
|
n (events)
|
P
b
|
P
c
|
All patients | | | | | | | | |
Low | 1.00 | 105 (48) | | | 1.00 | 99 (45) | | |
High | 0.69 (0.49 to 0.96) | 422 (134) | 0.026 | 0.024 | 1.08 (0.75 to 1.58) | 377 (113) | 0.671 | 0.429 |
Female | | | | | | | | |
Low | | 1.00 | 50 (17) | | | 1.00 | 47 (16) | |
High | 1.05 (0.62 to 1.78) | 226 (73) | 0.864 | | 1.35 (0.75 to 2.41) | 199 (60) | 0.313 | |
Male | | | | | | | | |
Low | | 1.00 | 55 (31) | | | 1.00 | 52 (29) | |
High | 0.48 (0.31 to 0.74) | 196 (61) | < 0.001 | | 0.90 (0.53 to 1.53) | 178 (53) | 0.712 | |
- Abbreviations: HR = hazard ratio.
-
a
P value from multivariate analysis adjusted for T stage (1 to 2 versus 3 to 4), N stage (0 versus 1 to 2), M stage (0 versus1), age (≤ or ≥ 75 years), differentiation grade (high to intermediate versus low) and vascular invasion (absent, present, missing). Sex was included in the multivariate analysis for all patients.
-
b
P value for term of interaction by Cox multivariate analysis including gender, the binary covariate cyclin D1 expression and a term of interaction.
-
c
P value for term of interaction adjusted for T stage (1 to 2 versus 3 to 4), N stage (0 versus 1 to 2), M stage (0 versus1), age (≤ or ≥ 75 years), differentiation grade (high to intermediate versus low) and vascular invasion (absent, present, missing).