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Table 3 Cox univarate and multivariate proportional hazards analysis of colorectal cancer-specific survival in all patients

From: Cyclin D1 expression in colorectal cancer is a favorable prognostic factor in men but not in women in a prospective, population-based cohort study

Cyclin D1 expression

Univariate

Multivariate

 

HR (95%CI)

n (events)

P

P a

HR (95%CI)

n (events)

P b

P c

All patients

        

   Low

1.00

105 (48)

  

1.00

99 (45)

  

   High

0.69 (0.49 to 0.96)

422 (134)

0.026

0.024

1.08 (0.75 to 1.58)

377 (113)

0.671

0.429

Female

        

   Low

 

1.00

50 (17)

  

1.00

47 (16)

 

   High

1.05 (0.62 to 1.78)

226 (73)

0.864

 

1.35 (0.75 to 2.41)

199 (60)

0.313

 

Male

        

   Low

 

1.00

55 (31)

  

1.00

52 (29)

 

   High

0.48 (0.31 to 0.74)

196 (61)

< 0.001

 

0.90 (0.53 to 1.53)

178 (53)

0.712

 
  1. Abbreviations: HR = hazard ratio.
  2. a P value from multivariate analysis adjusted for T stage (1 to 2 versus 3 to 4), N stage (0 versus 1 to 2), M stage (0 versus1), age (≤ or ≥ 75 years), differentiation grade (high to intermediate versus low) and vascular invasion (absent, present, missing). Sex was included in the multivariate analysis for all patients.
  3. b P value for term of interaction by Cox multivariate analysis including gender, the binary covariate cyclin D1 expression and a term of interaction.
  4. c P value for term of interaction adjusted for T stage (1 to 2 versus 3 to 4), N stage (0 versus 1 to 2), M stage (0 versus1), age (≤ or ≥ 75 years), differentiation grade (high to intermediate versus low) and vascular invasion (absent, present, missing).