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Table 3 Cox univarate and multivariate proportional hazards analysis of colorectal cancer-specific survival in all patients

From: Cyclin D1 expression in colorectal cancer is a favorable prognostic factor in men but not in women in a prospective, population-based cohort study

Cyclin D1 expression Univariate Multivariate
  HR (95%CI) n (events) P P a HR (95%CI) n (events) P b P c
All patients         
   Low 1.00 105 (48)    1.00 99 (45)   
   High 0.69 (0.49 to 0.96) 422 (134) 0.026 0.024 1.08 (0.75 to 1.58) 377 (113) 0.671 0.429
Female         
   Low   1.00 50 (17)    1.00 47 (16)  
   High 1.05 (0.62 to 1.78) 226 (73) 0.864   1.35 (0.75 to 2.41) 199 (60) 0.313  
Male         
   Low   1.00 55 (31)    1.00 52 (29)  
   High 0.48 (0.31 to 0.74) 196 (61) < 0.001   0.90 (0.53 to 1.53) 178 (53) 0.712  
  1. Abbreviations: HR = hazard ratio.
  2. a P value from multivariate analysis adjusted for T stage (1 to 2 versus 3 to 4), N stage (0 versus 1 to 2), M stage (0 versus1), age (≤ or ≥ 75 years), differentiation grade (high to intermediate versus low) and vascular invasion (absent, present, missing). Sex was included in the multivariate analysis for all patients.
  3. b P value for term of interaction by Cox multivariate analysis including gender, the binary covariate cyclin D1 expression and a term of interaction.
  4. c P value for term of interaction adjusted for T stage (1 to 2 versus 3 to 4), N stage (0 versus 1 to 2), M stage (0 versus1), age (≤ or ≥ 75 years), differentiation grade (high to intermediate versus low) and vascular invasion (absent, present, missing).