|
Cyclin D1 expression
|
Univariate
|
Multivariate
|
|---|
| |
HR (95%CI)
|
n (events)
|
P
|
P
a
|
HR (95%CI)
|
n (events)
|
P
b
|
P
c
|
|
All patients
| | | | | | | | |
|
Low
|
1.00
|
105 (48)
| | |
1.00
|
99 (45)
| | |
|
High
|
0.69 (0.49 to 0.96)
|
422 (134)
|
0.026
|
0.024
|
1.08 (0.75 to 1.58)
|
377 (113)
|
0.671
|
0.429
|
|
Female
| | | | | | | | |
|
Low
| |
1.00
|
50 (17)
| | |
1.00
|
47 (16)
| |
|
High
|
1.05 (0.62 to 1.78)
|
226 (73)
|
0.864
| |
1.35 (0.75 to 2.41)
|
199 (60)
|
0.313
| |
|
Male
| | | | | | | | |
|
Low
| |
1.00
|
55 (31)
| | |
1.00
|
52 (29)
| |
|
High
|
0.48 (0.31 to 0.74)
|
196 (61)
|
< 0.001
| |
0.90 (0.53 to 1.53)
|
178 (53)
|
0.712
| |
- Abbreviations: HR = hazard ratio.
-
a
P value from multivariate analysis adjusted for T stage (1 to 2 versus 3 to 4), N stage (0 versus 1 to 2), M stage (0 versus1), age (≤ or ≥ 75 years), differentiation grade (high to intermediate versus low) and vascular invasion (absent, present, missing). Sex was included in the multivariate analysis for all patients.
-
b
P value for term of interaction by Cox multivariate analysis including gender, the binary covariate cyclin D1 expression and a term of interaction.
-
c
P value for term of interaction adjusted for T stage (1 to 2 versus 3 to 4), N stage (0 versus 1 to 2), M stage (0 versus1), age (≤ or ≥ 75 years), differentiation grade (high to intermediate versus low) and vascular invasion (absent, present, missing).
