Figure 7
Renal angiotensin converting enzyme 2 (ACE2) activity in the four core genotypes (FCG) in the intact and GDX state treated with and without oestradiol (E 2 ). Shown are the mean ± standard error of mean for renal ACE2 activity in gonadally intact (open bars), GDX (striped bars) and E2 treated GDX (hatched bars) FCG mice; n = 6/group. ANOVA analyses revealed a significant effect of sex (P < 0.001, *intact-female versus intact-male), gonadectomy in the female (P < 0.001, #intact-female versus GDX-F) and E2 treatment in all GDX mice (P < 0.001, ‡GDX+E2 versus GDX) on renal ACE2 activity (see Results for details).