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  1. Research

    Impact of gonadectomy on blood pressure regulation in ageing male and female rats

    Sexual dimorphism in blood pressure has been associated with differential expression of the angiotensin II (AII) receptors and with activity of the nervous system. It is generally accepted that ageing affects ...

    Wioletta Pijacka, Bethan Clifford, Dawid Walas, Chantal Tilburgs, Jaap A. Joles, Sarah McMullen and Simon C. Langley-Evans

    Biology of Sex Differences 2016 7:64

    Published on: 3 December 2016

  2. Research

    Sex-related differences in the associations between plasma free fatty acid levels and clinical features in patients with hypertrophic cardiomyopathy

    Previous studies have indicated that inefficient energy utilization may play a pivotal role in hypertrophic cardiomyopathy (HCM). However, whether plasma free fatty acid (FFA), a main energy substrate of heart...

    Chengzhi Yang, Changlin Zhang, Jiansong Yuan, Jingang Cui, Shengwen Liu, Fenghuan Hu, Weixian Yang, Xuanye Bi and Shubin Qiao

    Biology of Sex Differences 2016 7:63

    Published on: 25 November 2016

  3. Research

    Sex differences in outcomes after stroke among patients with low total cholesterol levels: a large hospital-based prospective study

    Previous studies have shown that total cholesterol (TC) levels are associated with stroke outcomes, but sex differences in the association between TC levels, especially a low TC level, and ischemic stroke outc...

    Guanen Zhou, Zhongping An, Wenjuan Zhao, Yan Hong, Haolin Xin, Xianjia Ning and Jinghua Wang

    Biology of Sex Differences 2016 7:62

    Published on: 24 November 2016

  4. Research

    Comparisons of chromosome Y-substituted mouse strains reveal that the male-specific chromosome modulates the effects of androgens on cardiac functions

    The C57BL/6J.YA/J mouse strain is a chromosome-substituted line where the original male-specific portion of chromosome Y (MSY) from C57BL/6J mice was substituted for that from A/J mice. In hearts from male C57BL/...

    Samantha D. Praktiknjo, Sylvie Picard and Christian F. Deschepper

    Biology of Sex Differences 2016 7:61

    Published on: 23 November 2016

  5. Research

    Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress

    Biological sex plays a prominent role in the prevalence and severity of a number of important stress-related gastrointestinal and immune-related diseases including IBS and allergy/anaphylaxis. Despite the esta...

    Emily Mackey, Saravanan Ayyadurai, Calvin S. Pohl, Susan D’ Costa, Yihang Li and Adam J. Moeser

    Biology of Sex Differences 2016 7:60

    Published on: 22 November 2016

  6. Research

    Gene-specific sex effects on eosinophil infiltration in leishmaniasis

    Sex influences susceptibility to many infectious diseases, including some manifestations of leishmaniasis. The disease is caused by parasites that enter to the skin and can spread to the lymph nodes, spleen, l...

    Martina Slapničková, Valeriya Volkova, Marie Čepičková, Tatyana Kobets, Matyáš Šíma, Milena Svobodová, Peter Demant and Marie Lipoldová

    Biology of Sex Differences 2016 7:59

    Published on: 22 November 2016

  7. Research

    Sex- and age-related differences in arterial pressure and albuminuria in mice

    Animal models have become valuable experimental tools for understanding the pathophysiology and therapeutic interventions in cardiovascular disease. Yet to date, few studies document the age- and sex-related d...

    Giannie Barsha, Kate M. Denton and Katrina M. Mirabito Colafella

    Biology of Sex Differences 2016 7:57

    Published on: 14 November 2016

  8. Letter to the Editor

    The p.R92W variant of NR5A1/Nr5a1 induces testicular development of 46,XX gonads in humans, but not in mice: phenotypic comparison of human patients and mutation-induced mice

    NR5A1 is the key regulator of adrenal and gonadal development in both humans and mice. Recently, a missense substitution in human NR5A1, p.R92W, was shown to underlie gonadal dysgenesis in genetic males and testi...

    Mami Miyado, Masafumi Inui, Maki Igarashi, Yuko Katoh-Fukui, Kei Takasawa, Akiko Hakoda, Junko Kanno, Kenichi Kashimada, Kenji Miyado, Moe Tamano, Tsutomu Ogata, Shuji Takada and Maki Fukami

    Biology of Sex Differences 2016 7:56

    Published on: 8 November 2016

  9. Commentary

    Workshop summaries from the 2015 Sex and Gender Medical Education Summit: utilization of sex and gender based medical education resources and creating student competencies

    Despite overwhelming evidence that sex and gender are critical factors in the delivery and practice of medicine, there is no unified sex- and gender-based medicine (SGBM) undergraduate medical education curric...

    Alyson J. McGregor, Ana Núñez, Rebecca Barron, Robert Casanova and Eliza Lo Chin

    Biology of Sex Differences 2016 7(Suppl 1):43

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  10. Commentary

    Instructional design framework for the sex and gender-specific health multimedia case-based learning modules

    The goal of the Sex and Gender Specific Health (SGSH) curriculum at the Texas Tech University Health Sciences Center (TTUHSC) is to advance the understanding of sex/gender differences, increase the awareness o...

    Steven M. Crooks, Jongpil Cheon, Robert Casanova and Marjorie Jenkins

    Biology of Sex Differences 2016 7(Suppl 1):49

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  11. Commentary

    Innovative levers for sustainable integration of gender medicine into medical school curricula

    Efforts to integrate gender medicine into medical school curricula have focused largely on the work of individual champions. Online sex and gender materials for undergraduate courses have also been developed a...

    Cara Tannenbaum and Geneviève Moineau

    Biology of Sex Differences 2016 7(Suppl 1):41

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  12. Commentary

    Auditing sex- and gender-based medicine (SGBM) content in medical school curriculum: a student scholar model

    Sex- and gender-based medicine (SGBM) aims to (1) delineate and investigate sex- and gender-based differences in health, disease, and response to treatment and (2) apply that knowledge to clinical care to impr...

    Michael M. Song, Betsy G. Jones and Robert A. Casanova

    Biology of Sex Differences 2016 7(Suppl 1):40

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  13. Research

    Training emergency physicians in sex- and gender-based medicine: assessing attitudes of program directors and residency graduates

    Sex and gender influence disease presentation, treatment, healthcare access, and long-term outcomes. It is uncertain to what extent sex- and gender-based medicine (SGBM) content has been integrated into emerge...

    Tracy E. Madsen and Alyson J. McGregor

    Biology of Sex Differences 2016 7(Suppl 1):48

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  14. Commentary

    Integrating topics of sex and gender into medical curricula—lessons from the international community

    In the era of individualized medicine, training future scientists and health-care providers in the principles of sex- and gender-based differences in health and disease is critical in order to optimize patient...

    Virginia M. Miller, Georgios Kararigas, Ute Seeland, Vera Regitz-Zagrosek, Karolina Kublickiene, Gillian Einstein, Robert Casanova and Marianne J. Legato

    Biology of Sex Differences 2016 7(Suppl 1):44

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  15. Research

    The science of sex and gender in human health: online courses to create a foundation for sex and gender accountability in biomedical research and treatment

    Sex and gender differences play a significant role in the course and outcome of conditions that affect specific organ systems in the human body. Research on differences in the effects of medical intervention h...

    Jennifer L. Plank-Bazinet, Annie Sampson, Leah R. Miller, Emmanuel O. Fadiran, Deborah Kallgren, Rajeev K. Agarwal, Whitney Barfield, Claudette E. Brooks, Lisa Begg, Amy C. Mistretta, Pamela E. Scott, Janine Austin Clayton and Terri L. Cornelison

    Biology of Sex Differences 2016 7(Suppl 1):47

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  16. Research

    Sex and gender medicine in physician clinical training: results of a large, single-center survey

    “Sex and Gender Medicine” is a novel medical discipline that takes into account the effects of sex and gender on the health of women and men. The Institute of Medicine in the USA declared in its 2001 and 2010 ...

    Shivani Dhawan, May Bakir, Erika Jones, Sarah Kilpatrick and C. Noel Bairey Merz

    Biology of Sex Differences 2016 7(Suppl 1):37

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  17. Commentary

    eGender—from e-Learning to e-Research: a web-based interactive knowledge-sharing platform for sex- and gender-specific medical education

    Sex and Gender Medicine is a novel discipline that provides equitable medical care for society and improves outcomes for both male and female patients. The integration of sex- and gender-specific knowledge int...

    Ute Seeland, Ahmad T. Nauman, Alissa Cornelis, Sabine Ludwig, Mathias Dunkel, Georgios Kararigas and Vera Regitz-Zagrosek

    Biology of Sex Differences 2016 7(Suppl 1):39

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  18. Research

    Evaluation of sex- and gender-based medicine training in post-graduate medical education: a cross-sectional survey study

    Addressing healthcare disparities is a national priority for initiatives in precision and individualized medicine. An essential component of precision medicine is the understanding that sex and gender influenc...

    Juliana M. Kling, Steven H. Rose, Lisa N. Kransdorf, Thomas R. Viggiano and Virginia M. Miller

    Biology of Sex Differences 2016 7(Suppl 1):38

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  19. Commentary

    Sex and Gender Medical Education Summit: a roadmap for curricular innovation

    The Sex and Gender Medical Education Summit: a roadmap for curricular innovation was a collaborative initiative of the American Medical Women's Association, Laura W. Bush Institute for Women’s Health, Mayo Cli...

    Eliza L. Chin, Marley Hoggatt, Alyson J. McGregor, Mary K. Rojek, Kimberly Templeton, Robert Casanova, Wendy S. Klein, Virginia M. Miller and Marjorie Jenkins

    Biology of Sex Differences 2016 7(Suppl 1):52

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  20. Review

    How to study the impact of sex and gender in medical research: a review of resources

    There is a growing appreciation by the biomedical community that studying the impact of sex and gender on health, aging, and disease will lead to improvements in human health. Sex- and gender-based comparisons...

    Alyson J. McGregor, Memoona Hasnain, Kathryn Sandberg, Mary F. Morrison, Michelle Berlin and Justina Trott

    Biology of Sex Differences 2016 7(Suppl 1):46

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  21. Research

    Sex and gender in medical education: a national student survey

    Gender- and sex-specific medicine is defined as the practice of medicine based on the understanding that biology (dictated by sex chromosomes) and social roles (gender) are important in and have implications f...

    Marjorie R. Jenkins, Alyssa Herrmann, Amanda Tashjian, Tina Ramineni, Rithika Ramakrishnan, Donna Raef, Tracy Rokas and John Shatzer

    Biology of Sex Differences 2016 7(Suppl 1):45

    Published on: 14 October 2016

    This article is part of a Supplement: Volume 7 Supplement 1

  22. Research

    In utero origin of sex-related differences in future cardiovascular disease

    There are sex differences in the risk of development of cardiovascular disease (CVD). According to the developmental origins of health and disease paradigm (DOHaD), CVD originates in fetal life. This study exa...

    Sarah Schalekamp-Timmermans, Jerome Cornette, Albert Hofman, Willem A. Helbing, Vincent W. V. Jaddoe, Eric A. P. Steegers and Bero O. Verburg

    Biology of Sex Differences 2016 7:55

    Published on: 13 October 2016

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